Nilsson-Håkansson L, Lai Z, Nordberg A
Department of Pharmacology, University of Uppsala, Sweden.
Eur J Pharmacol. 1990 Sep 21;186(2-3):301-5. doi: 10.1016/0014-2999(90)90448-f.
Rats were treated with 10 mg/kg tetrahydroaminoacridine (THA) twice daily for 14 days. THA (10 mg/kg) induced a significant decrease in the number of muscarinic receptors (both M1 and M2) in the cortex and striatum, whereas the number of nicotinic receptors in the cortex and hippocampus increased. Rats treated with physostigmine (0.9 mg/kg) showed a reduced number of muscarinic receptors, but no change in nicotinic receptors. The results indicate that treatment with cholinesterase inhibitors can induce opposite changes in brain muscarinic and nicotinic receptors in vivo.
大鼠每天两次接受10毫克/千克的四氢氨基吖啶（THA）治疗，持续14天。THA（10毫克/千克）导致皮质和纹状体中M1和M2型毒蕈碱受体数量显著减少，而皮质和海马体中的烟碱受体数量增加。用毒扁豆碱（0.9毫克/千克）治疗的大鼠毒蕈碱受体数量减少，但烟碱受体数量没有变化。结果表明，胆碱酯酶抑制剂治疗可在体内诱导脑内毒蕈碱和烟碱受体产生相反的变化。
