Costello K B, Stewart D J, Baffour R
Department of Medicine, McGill University, Montreal, Canada.
Eur J Pharmacol. 1990 Sep 21;186(2-3):311-4. doi: 10.1016/0014-2999(90)90450-k.
We studied the interaction of endothelin and endothelium-derived relaxing factor (EDRF) in human saphenous veins and internal mammary arteries using isolated ring preparations. Endothelin was a more potent constrictor of human internal mammary arteries and saphenous veins than norepinephrine. The ability of acetylcholine to reverse endothelin-induced contraction was greater in the internal mammary arteries than in saphenous veins. However, nitroprusside produced similar and near-complete inhibition of endothelin precontraction in both arteries and veins. We conclude that endothelin is a potent constricting agent in human internal mammary arteries and saphenous veins in vitro. Endothelin-induced vasoconstriction is effectively inhibited by EDRF, but human saphenous veins appear to have limited capability for endothelium-dependent dilation.
我们使用离体血管环标本研究了内皮素与内皮源性舒张因子（EDRF）在人隐静脉和乳内动脉中的相互作用。内皮素对人乳内动脉和隐静脉的收缩作用比去甲肾上腺素更强。乙酰胆碱逆转内皮素诱导的收缩的能力在乳内动脉中比在隐静脉中更强。然而，硝普钠对动脉和静脉中内皮素预收缩的抑制作用相似且接近完全。我们得出结论，内皮素在体外是人乳内动脉和隐静脉中的一种强效收缩剂。内皮素诱导的血管收缩被EDRF有效抑制，但人隐静脉似乎具有有限的内皮依赖性舒张能力。
