McNamara D B, Light J T, Minkes R K, Saroyan R M, Kvamme P, Rowe N, Webb W R, Fox L, Kerstein M D, Mills N L
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Lousiana 70112.
Mol Cell Biochem. 1992 Nov 4;117(1):81-5. doi: 10.1007/BF00230413.
The effects of endothelin (ET-1) on smooth muscle contractile activity were investigated and compared in human saphenous vein and gastroepiploic artery, vessels frequently used in revascularization procedures. ET-1 contracted saphenous vein and gastroepiploic artery in a concentration-dependent manner. The peptide produced a greater maximal effect in the vein than in the artery and, in both preparations, ET-1 was less efficacious than U46619, an agent which mimics the actions of thromboxane A2 at the thromboxane A2/prostaglandin H2 receptor. The contractile response to ET-1 declined spontaneously at a more rapid rate in the artery than in the vein. The present data indicate that ET-1 has significant contractile activity in both vessels which are used for coronary arterial bypass surgery and suggest that although, a weaker vasoconstrictor than U46619, the peptide could induce vasospasm in both graft vessels.
在内皮素（ET - 1）对平滑肌收缩活性的影响方面，我们对人体大隐静脉和胃网膜动脉进行了研究和比较，这两种血管常用于血管重建手术。ET - 1以浓度依赖的方式使大隐静脉和胃网膜动脉收缩。该肽在静脉中产生的最大效应比在动脉中更大，并且在两种制剂中，ET - 1的效力均低于U46619，U46619是一种在血栓素A2/前列腺素H2受体处模拟血栓素A2作用的药物。在动脉中，对ET - 1的收缩反应比在静脉中以更快的速度自发下降。目前的数据表明，ET - 1在用于冠状动脉搭桥手术的两种血管中均具有显著的收缩活性，并表明尽管该肽作为血管收缩剂比U46619弱，但它可能在两种移植血管中诱发血管痉挛。
