胆固醇血浆水平与海洛因使用者的渴望之间的关系。
Association between cholesterol plasma levels and craving among heroin users.
机构信息
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
J Addict Med. 2012 Dec;6(4):287-91. doi: 10.1097/ADM.0b013e318262a9a1.
OBJECTIVE
Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving.
METHOD
The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed.
RESULTS
Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively).
CONCLUSIONS
Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.
目的
脂质可能在与药物成瘾相关的中枢神经系统功能中发挥作用。迄今为止，胆固醇被认为会影响可卡因使用的复发。然而，胆固醇和海洛因渴求之间的关系尚不清楚。本研究探讨了胆固醇和渴求之间的并发关联。
方法
测量了 70 名正在接受或已经接受美沙酮维持治疗的海洛因使用者的血清脂质水平。评估了他们的渴望和人口统计学数据。
结果
在控制潜在混杂因素的影响之前（r = -0.33，P < 0.01 和 r = -0.36，P < 0.01）和之后，总胆固醇和低密度脂蛋白胆固醇与渴望呈负相关（β = -0.38，P < 0.01 和 β = -0.42，P < 0.01）。
结论
胆固醇可能与渴望的认知方面有关，并且可能是预测药物复发风险的潜在标志物。
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