Department of Pharmacology, Medical School of Southeast University, Nanjing, China.
Department of Clinical Laboratory, Zhongda Hospital, Southeast University School of Medicine, Nanjing, 210009, Jiangsu, China.
Metab Brain Dis. 2018 Oct;33(5):1585-1597. doi: 10.1007/s11011-018-0265-8. Epub 2018 Jun 26.
Methamphetamine is a popular psychostimulant worldwide which causes neurotoxicity and neuroinflammation. Although previous studies have characterized potential associations between addictive drugs and fasting blood glucose, the influence of methamphetamine on the blood glucose is still largely unknown. The present study was designed to investigate the change of fasting blood glucose of methamphetamine abusers and to confirm the impairment of liver and kidney. Fasting blood glucose was significantly decreased in methamphetamine abusers and in a high-fat diet mouse model with methamphetamine treatment discontinuation. Serum level of ALT, creatine kinase and creatinine were increased in methamphetamine abusers. Serum level of ALT and AST were increased in a high-fat diet mouse model after methamphetamine injection, but there was no significant difference in the anatomy of the liver and kidney in high-fat diet treated mice with or without methamphetamine. The levels of ALT and creatinine were also increased in the methamphetamine abusers. This study demonstrated that the level of glucose was decreased in methamphetamine abusers and in high-fat diet-fed mice after methamphetamine treatment discontinuation. The effect of methamphetamine on the levels of blood glucose may provide the evidence that methamphetamine abusers should be keep energy balance due to the low blood glucose.
甲基苯丙胺是一种在世界范围内流行的精神兴奋剂，会导致神经毒性和神经炎症。虽然先前的研究已经描述了成瘾药物与空腹血糖之间的潜在关联，但甲基苯丙胺对血糖的影响在很大程度上仍然未知。本研究旨在调查甲基苯丙胺滥用者的空腹血糖变化，并证实其对肝脏和肾脏的损害。甲基苯丙胺滥用者和停止甲基苯丙胺治疗的高脂肪饮食小鼠模型的空腹血糖均显著降低。甲基苯丙胺滥用者的血清丙氨酸氨基转移酶（ALT）、肌酸激酶和肌酐水平升高。在高脂肪饮食的小鼠中注射甲基苯丙胺后，血清 ALT 和 AST 水平升高，但高脂肪饮食治疗的小鼠的肝脏和肾脏解剖结构无明显差异。甲基苯丙胺滥用者的 ALT 和肌酐水平也升高。本研究表明，在甲基苯丙胺滥用者和停止甲基苯丙胺治疗后的高脂肪饮食喂养的小鼠中，血糖水平降低。甲基苯丙胺对血糖水平的影响可能为甲基苯丙胺滥用者由于低血糖应保持能量平衡提供了证据。
