Laboratory of Translational Oncology and Functional Genomics, Section of Pathology and Oncology, Department of Biomedical Sciences, University of Catania, Catania, Italy.
Int J Mol Med. 2012 Nov;30(5):991-9. doi: 10.3892/ijmm.2012.1089. Epub 2012 Aug 8.
Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.
尽管甲状腺癌的治疗近年来取得了进展，但这种肿瘤的存活率仍有可能提高。因此，确定惰性和侵袭性疾病的生物学和分子特征对于确定高危病变的临床有用预测因子至关重要。microRNAs (miRNAs) 是具有调节功能和明显组织特异性的小 RNA 分子，可调节属于多个途径的多个靶标。它们在癌症中经常失调，构成了一类新的基于血液的生物标志物，可用于癌症检测和预后定义，包括甲状腺癌。在这篇综述中，描述了 miRNAs 在甲状腺癌发展中的作用。还讨论了在甲状腺癌中检测到的最常见的 miRNAs 及其临床意义。旨在检测甲状腺癌患者血浆中 miRNA 生物标志物的进一步研究可能为甲状腺癌的治疗提供更多的见解。
