Medical Institute of Paediatrics, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, PR China.
Mol Med Rep. 2012 Nov;6(5):1093-8. doi: 10.3892/mmr.2012.1028. Epub 2012 Aug 9.
Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder in children and adolescents; however, its etiology is unknown. In this study, we investigated the association of five polymorphisms in dopaminergic/GABAergic genes with ADHD using polymerase chain reaction-restriction fragment length polymorphism in a group of 54 children with ADHD and 67 healthy controls. The distribution of AA genotype and A allele frequencies of rs5320 in the dopamine beta-hydroxylase gene in ADHD children differed significantly from that in healthy controls; however, no associations were found between four other polymorphisms in dopaminergic/GABAergic genes and ADHD. We also identified the best model consisting of four loci. We conclude that the rs5320 polymorphism may be considered as a genetic risk factor of ADHD, but the other four polymorphisms were not confirmed to be related directly to ADHD. The multilocus of dopaminergic/GABAergic genes acted in combination to affect susceptibility to ADHD in the children studied.
注意缺陷多动障碍（ADHD）是儿童和青少年中最常见的神经行为障碍；然而，其病因尚不清楚。在这项研究中，我们使用聚合酶链反应-限制性片段长度多态性，在 54 名 ADHD 儿童和 67 名健康对照组中，研究了多巴胺能/GABA 能基因中的五个多态性与 ADHD 的相关性。ADHD 儿童多巴胺β羟化酶基因 rs5320 的 AA 基因型和 A 等位基因频率分布与健康对照组有显著差异；然而，多巴胺能/GABA 能基因的其他四个多态性与 ADHD 之间没有关联。我们还确定了由四个基因座组成的最佳模型。我们的结论是，rs5320 多态性可以被认为是 ADHD 的遗传风险因素，但其他四个多态性不能被证实与 ADHD 直接相关。多巴胺能/GABA 能基因的多基因座联合作用，影响了所研究儿童对 ADHD 的易感性。
