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本文引用的文献

1
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques.甲硝唑可预防潜伏性结核分枝杆菌感染在猕猴体内的再激活。
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14188-93. doi: 10.1073/pnas.1121497109. Epub 2012 Jul 23.
2
Targeting persisters for tuberculosis control.针对结核分枝杆菌持续感染的治疗策略。
Antimicrob Agents Chemother. 2012 May;56(5):2223-30. doi: 10.1128/AAC.06288-11. Epub 2012 Mar 5.
3
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.潜伏性结核的范围：重新思考生物学和干预策略。
Nat Rev Microbiol. 2009 Dec;7(12):845-55. doi: 10.1038/nrmicro2236. Epub 2009 Oct 26.
4
Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis.在肺结核强化期治疗中用莫西沙星替代异烟肼。
Am J Respir Crit Care Med. 2009 Aug 1;180(3):273-80. doi: 10.1164/rccm.200901-0078OC. Epub 2009 Apr 30.
5
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.甲硝唑对感染结核分枝杆菌的豚鼠缺乏抗菌活性。
Antimicrob Agents Chemother. 2008 Nov;52(11):4137-40. doi: 10.1128/AAC.00196-08. Epub 2008 Aug 11.
6
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.二芳基喹啉类药物由于破坏了ATP稳态而对休眠分枝杆菌具有杀菌作用。
J Biol Chem. 2008 Sep 12;283(37):25273-25280. doi: 10.1074/jbc.M803899200. Epub 2008 Jul 14.
7
Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency.在潜伏性体内缺氧性肉芽肿模型中，甲硝唑对结核分枝杆菌无活性。
J Infect Dis. 2008 Jul 15;198(2):275-83. doi: 10.1086/589515.
8
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.在豚鼠、兔子和非人灵长类动物中，结核性肉芽肿处于缺氧状态。
Infect Immun. 2008 Jun;76(6):2333-40. doi: 10.1128/IAI.01515-07. Epub 2008 Mar 17.
9
Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.在小鼠结核病模型中，含PA - 824、莫西沙星和吡嗪酰胺的治疗方案具有强大的杀菌和灭菌活性。
Antimicrob Agents Chemother. 2008 Apr;52(4):1522-4. doi: 10.1128/AAC.00074-08. Epub 2008 Feb 19.
10
Advances in the treatment of tuberculosis.结核病治疗的进展。
Clin Pharmacol Ther. 2007 Nov;82(5):595-600. doi: 10.1038/sj.clpt.6100362. Epub 2007 Sep 26.

Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.

作者信息

Zhang Ying

机构信息

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

出版信息

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13890-1. doi: 10.1073/pnas.1211081109. Epub 2012 Aug 15.

DOI:10.1073/pnas.1211081109
PMID:22895789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3435169/
Abstract
摘要