Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.
作者信息
Zhang Ying
机构信息
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13890-1. doi: 10.1073/pnas.1211081109. Epub 2012 Aug 15.
Abstract
摘要
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本文引用的文献
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Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14188-93. doi: 10.1073/pnas.1121497109. Epub 2012 Jul 23.
2
Targeting persisters for tuberculosis control.针对结核分枝杆菌持续感染的治疗策略。
Antimicrob Agents Chemother. 2012 May;56(5):2223-30. doi: 10.1128/AAC.06288-11. Epub 2012 Mar 5.
3
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.潜伏性结核的范围：重新思考生物学和干预策略。
Nat Rev Microbiol. 2009 Dec;7(12):845-55. doi: 10.1038/nrmicro2236. Epub 2009 Oct 26.
4
Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis.在肺结核强化期治疗中用莫西沙星替代异烟肼。
Am J Respir Crit Care Med. 2009 Aug 1;180(3):273-80. doi: 10.1164/rccm.200901-0078OC. Epub 2009 Apr 30.
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Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.二芳基喹啉类药物由于破坏了ATP稳态而对休眠分枝杆菌具有杀菌作用。
J Biol Chem. 2008 Sep 12;283(37):25273-25280. doi: 10.1074/jbc.M803899200. Epub 2008 Jul 14.
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Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency.在潜伏性体内缺氧性肉芽肿模型中，甲硝唑对结核分枝杆菌无活性。
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Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.在豚鼠、兔子和非人灵长类动物中，结核性肉芽肿处于缺氧状态。
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