甲硝唑对感染结核分枝杆菌的豚鼠缺乏抗菌活性。
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
作者信息
Hoff Donald R, Caraway Megan L, Brooks Elizabeth J, Driver Emily R, Ryan Gavin J, Peloquin Charles A, Orme Ian M, Basaraba Randall J, Lenaerts Anne J
机构信息
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
Antimicrob Agents Chemother. 2008 Nov;52(11):4137-40. doi: 10.1128/AAC.00196-08. Epub 2008 Aug 11.
Abstract
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
摘要
甲硝唑用于治疗由厌氧菌引起的感染，在感染结核分枝杆菌的豚鼠身上进行了评估。结核分枝杆菌能够适应低氧环境，这种环境存在于受感染豚鼠的原发性病灶中。甲硝唑治疗（以100毫克/千克体重的剂量持续6周）并未使细菌负荷降低，反而显著加重了病灶炎症。
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