成像线粒体氧化还原电位及其与肿瘤转移潜能的可能联系。
Imaging mitochondrial redox potential and its possible link to tumor metastatic potential.
机构信息
Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
J Bioenerg Biomembr. 2012 Dec;44(6):645-53. doi: 10.1007/s10863-012-9469-5.
Abstract
Cellular redox states can regulate cell metabolism, growth, differentiation, motility, apoptosis, signaling pathways, and gene expressions etc. A growing body of literature suggest the importance of redox status for cancer progression. While most studies on redox state were done on cells and tissue lysates, it is important to understand the role of redox state in a tissue in vivo/ex vivo and image its heterogeneity. Redox scanning is a clinical-translatable method for imaging tissue mitochondrial redox potential with a submillimeter resolution. Redox scanning data in mouse models of human cancers demonstrate a correlation between mitochondrial redox state and tumor metastatic potential. I will discuss the significance of this correlation and possible directions for future research.
摘要
细胞的氧化还原状态可以调节细胞代谢、生长、分化、迁移、凋亡、信号通路和基因表达等。越来越多的文献表明氧化还原状态对癌症进展的重要性。虽然大多数关于氧化还原状态的研究都是在细胞和组织裂解物上进行的，但了解氧化还原状态在体内/体外组织中的作用并对其异质性进行成像非常重要。氧化还原扫描是一种具有亚毫米分辨率的成像组织线粒体氧化还原电势的临床转化方法。在人类癌症的小鼠模型中，氧化还原扫描数据表明线粒体氧化还原状态与肿瘤转移潜能之间存在相关性。我将讨论这种相关性的意义以及未来研究的可能方向。
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