Bellentani S, Baldoni P, Petrella S, Tata C, Armocida C, Marchegiano P, Saccoccio G, Manenti F
Cattedra di Gastroenterologia, Universita' degli Studi di Modena, Italy.
Fam Pract. 1990 Dec;7(4):307-12. doi: 10.1093/fampra/7.4.307.
In order to develop a scoring system for selecting patients at high risk of organic diseases of the colon, who would need a colonoscopy or a barium enema, we conducted a study with 14 GPs in the local health care district of Modena. Over one year, 254 consecutive patients who consulted their GP for chronic abdominal pain were asked to answer a guided questionnaire. A checklist of simple parameters suggestive of the presence of organic diseases of the colon was also registered by the GP. For the final diagnosis, the patients underwent either a colonoscopy or a barium enema. Data collected were analysed by means of a stepwise logistic regression analysis to obtain a weighted score for the diagnosis of either irritable bowel syndrome (score less than 0) or organic disease (score greater than 0). Out of the 25 parameters explored, six were significantly more common among patients with organic disease and weighted as positive score (namely ESR greater than 17 mm, first hour, history of blood in the stool, leukocytosis greater than 10,000 cm3, age greater than 45 years, slight fever and presence of neoplastic colonic diseases in first-degree relatives). On the contrary, five parameters were more frequent among patients with irritable bowel syndrome and weighted as negative score (namely visible distension of the abdomen, feeling of distension, presence of irritable bowel syndrome in first degree relatives, flatulence and irregularities of bowel movement). Our scoring system correctly classified 83.5% of the cases, and it was very sensitive (82.4%) for the diagnosis of organic disease.(ABSTRACT TRUNCATED AT 250 WORDS)
为了开发一种评分系统,用于筛选需要进行结肠镜检查或钡灌肠的结肠器质性疾病高危患者,我们在摩德纳当地医疗保健区与14名全科医生开展了一项研究。在一年多的时间里,连续254名因慢性腹痛咨询全科医生的患者被要求回答一份指导性问卷。全科医生还记录了一份提示结肠器质性疾病存在的简单参数清单。为了得出最终诊断,患者接受了结肠镜检查或钡灌肠。收集到的数据通过逐步逻辑回归分析进行分析,以获得用于诊断肠易激综合征(评分小于0)或器质性疾病(评分大于0)的加权分数。在探索的25个参数中,有6个在器质性疾病患者中明显更常见,并被加权为正分数(即第一小时血沉超过17mm、便血史、白细胞增多超过10000/cm³、年龄超过45岁、低热以及一级亲属中有结肠肿瘤性疾病)。相反,有5个参数在肠易激综合征患者中更常见,并被加权为负分数(即腹部可见膨隆、腹胀感、一级亲属中有肠易激综合征、肠胃气胀和排便不规律)。我们的评分系统正确分类了83.5%的病例,并且对器质性疾病的诊断非常敏感(82.4%)。(摘要截断于250字)