用于亚细胞离子通道功能研究的笼锁细胞内NMDA受体阻滞剂。
Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function.
作者信息
Reeve James E, Kohl Michael M, Rodríguez-Moreno Antonio, Paulsen Ole, Anderson Harry L
出版信息
Commun Integr Biol. 2012 May 1;5(3):240-2. doi: 10.4161/cib.19400.
Abstract
We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology.
摘要
我们之前合成了一种光笼形式的依赖使用的N-甲基-D-天冬氨酸（NMDA）受体离子通道阻滞剂MK801，并利用该化合物的细胞内光解来证明参与突触可塑性的NMDA受体离子通道的亚细胞定位。在此，我们讨论关于光笼分子的选择、合成以及光笼离子通道阻滞剂在神经生理学中的潜在用途的相关考虑因素。
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