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毛细管区带电泳法快速测定药物制剂中的双氯芬酸

Rapid determination of diclofenac in pharmaceutical formulations by capillary zone electrophoresis.

作者信息

Lachmann Bodo, Kratzel Martin, Noe Christian R

机构信息

Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.

出版信息

Sci Pharm. 2012 Apr-Jun;80(2):311-6. doi: 10.3797/scipharm.1201-02. Epub 2012 Feb 23.

Abstract

Capillary electrophoresis is competitive to HPLC and other chromatographic methods, predominantly when charged analytes have to be separated. The time of analysis can be reduced by the use of very short capillaries applying a high voltage. In most instruments which are commercially available the so-called 'short end' of the capillary can be used for separation, leading to very rapid separations. In this contribution we want to demonstrate this approach by using Diclofenac Sodium as an analyte.

摘要

毛细管电泳与高效液相色谱法及其他色谱方法相比具有竞争力,主要适用于分离带电分析物。通过使用极短的毛细管并施加高电压,可以缩短分析时间。在大多数市售仪器中,毛细管的所谓“短端”可用于分离,从而实现非常快速的分离。在本论文中,我们想用双氯芬酸钠作为分析物来演示这种方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6026/3383214/63b43fc1ffa6/scipharm-2012-80-311f1.jpg

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