Marot J-C, Jonckheere S, Munyentwali H, Belkhir L, Vandercam B, Yombi J C
Department of Internal Medecine and Infectious Diseases, Cliniques Universitaires St Luc,
Acta Clin Belg. 2012 May-Jun;67(3):229-32. doi: 10.2143/ACB.67.3.2062663.
Tigecycline (formerly CAR-936, Tygacyl) is the first glycylcycline antibiotic available for clinical use. It has an expanded broad-spectrum antibiotic activity. Phase III studies have identified gastrointestinal side-effects, especially nausea and vomiting, as the most common adverse events. Few cases of acute pancreatitis (AP) have been described in the literature. We report two new cases of mild tigecycline-induced pancreatitis. Tigecycline was given for soft-tissue infection in both cases. Symptoms such as nausea, vomiting and mostly abdominal pain occurred within 5 days after starting Tigecycline. Pancreatic enzymes elevation occurred five to six days after initiation of treatment, and resolved within a week after drug-discontinuation. Diagnosis of mild pancreatitis was confirmed after performing CT-Scan of the abdomen in both cases. We take this opportunity to review the literature about this potentially serious side-effect induced by tigecycline.
替加环素（曾用名CAR - 936，商品名泰阁）是首个可供临床使用的甘氨酰环素类抗生素。它具有更广泛的广谱抗生素活性。Ⅲ期研究已确定胃肠道副作用，尤其是恶心和呕吐，是最常见的不良事件。文献中报道的急性胰腺炎（AP）病例很少。我们报告两例新的轻度替加环素诱导的胰腺炎病例。两例均因软组织感染而使用替加环素。在开始使用替加环素后的5天内出现恶心、呕吐等症状，主要是腹痛。治疗开始后五到六天出现胰腺酶升高，停药后一周内恢复正常。两例均经腹部CT扫描确诊为轻度胰腺炎。我们借此机会回顾了关于替加环素引起的这种潜在严重副作用的文献。
