Chu Pei-Yi, Liou Jia-Hung, Lin Yueh-Min, Chen Chih-Jung, Chen Mu-Kuan, Lin Shu-Hui, Yeh Chung-Min, Wang Hsin-Kai, Maa Ming-Chei, Leu Tzeng-Horng, Chang Nai-Wen, Hsu Nicholas C, Yeh Kun-Tu
Department of Pathology, St Martin De Porres Hospital, Chiayi.
Asia Pac J Clin Oncol. 2012 Dec;8(4):e77-81. doi: 10.1111/j.1743-7563.2011.01459.x. Epub 2012 Jan 12.
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a signaling protein implicated in the development of many human cancers including oral squamous cell carcinoma (OSCC). This study examined the expression of Eps8 and assessed its significance in patients with OSCC.
Immunohistochemical staining for Eps8 was conducted in 205 cases of OSCC collected over 7 years. The results were analyzed and correlated with patients' clinical outcomes.
We identified Eps8 expression in 186 of the 205 cases of OSCC (91%) and the aberrance occurred primarily in the cytoplasm of OSCC cells. Univariate analysis revealed that patients with Eps8 expression had significantly poorer 5-year overall survival (OS) than those without it (43% vs 74%, P = 0.014). Eps8 expression was also identified as an independent predictive factor for poorer OS by a multivariate analysis in regression modeling (P = 0.021, HR = 2.7). A Kaplan-Meier analysis showed that patients with positive Eps8 expression had a significantly poorer OS than patients with negative/low Eps8 expression (P = 0.038). The difference in disease-free survival between positive Eps8 expression and negative/low Eps8 expression nearly reached statistical significance (P = 0.051).
Eps8 is frequently expressed in OSCC. The aberrant expression of Eps8 closely correlated with poor survival in patients with OSCC.
表皮生长因子受体通路底物8（Eps8）是一种信号蛋白，与包括口腔鳞状细胞癌（OSCC）在内的多种人类癌症的发生发展有关。本研究检测了Eps8的表达，并评估其在OSCC患者中的意义。
对7年间收集的205例OSCC病例进行Eps8免疫组化染色。分析结果并与患者的临床结局相关联。
我们在205例OSCC病例中的186例（91%）中检测到Eps8表达，且异常主要发生在OSCC细胞的细胞质中。单因素分析显示，Eps8表达阳性的患者5年总生存率（OS）显著低于无Eps8表达的患者（43%对74%，P = 0.014）。在回归模型的多因素分析中，Eps8表达也被确定为OS较差的独立预测因素（P = 0.021，HR = 2.7）。Kaplan-Meier分析表明，Eps8表达阳性的患者OS显著低于Eps8表达阴性/低的患者（P = 0.038）。Eps8表达阳性与阴性/低表达患者的无病生存率差异接近统计学意义（P = 0.051）。
Eps8在OSCC中频繁表达。Eps8的异常表达与OSCC患者的不良生存密切相关。
