Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Head Neck. 2012 Sep;34(9):1340-5. doi: 10.1002/hed.21923. Epub 2011 Nov 2.
Src protein overexpression correlates with progression and prognosis of a variety of human cancers.
This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).
We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).
The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.
Src 蛋白的过表达与多种人类癌症的进展和预后相关。
本研究采用免疫组织化学方法检测了 93 例口腔鳞状细胞癌（OSCC）标本中 Src 蛋白的表达。
我们发现 Src 蛋白高表达（标记指数>50%）与肿瘤体积较大（p=0.017）、淋巴结转移阳性（p=0.030）、临床分期较晚（p=0.007）和复发（p<0.001）显著相关。多因素 Cox 回归分析表明，Src 蛋白高表达是独立的不良预后因素。Kaplan-Meier 曲线显示，Src 蛋白高表达的 OSCC 患者的累积生存率明显低于 Src 蛋白低表达的患者（对数秩检验，p=0.00267）。
Src 蛋白的表达与台湾 OSCC 的进展、复发和预后显著相关。
