Department of Food and Nutrition Science, Sagami Women's Junior College, Bunkyo, Minamiku, Sagamihara, Kanagawa, Japan.
Exp Dermatol. 2012 Sep;21(9):714-5. doi: 10.1111/j.1600-0625.2012.01559.x.
Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.
组胺有助于慢性变应性接触性皮炎中湿疹样损伤的发展。除了众所周知的皮质类固醇治疗外，H1 受体（H1R）拮抗剂也被使用。本研究在通过对背部皮肤重复经皮用 2,4,6-三硝基-1-氯苯（TNCB）进行挑战而建立的小鼠慢性变应性接触性皮炎模型中观察了 H1R 拮抗剂和 H4R 拮抗剂联合使用的效果。然后给予 H1R 拮抗剂盐酸奥洛他定和/或 H4R 拮抗剂 JNJ7777120。联合治疗比 H1R 拮抗剂单药治疗更有效。湿疹样病变中的血清 IgE 和白细胞介素（IL）-4、IL-5 和 IL-6（Th2 细胞因子）水平随联合治疗而降低。H1R 和 H4R 拮抗剂联合治疗可克服每种药物作为单药治疗的缺点，可能为慢性变应性接触性皮炎的治疗提供新策略。
