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The discovery of quinoline based single-ligand human H and H receptor antagonists.基于喹啉的单配体人H和H受体拮抗剂的发现。
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5855-5859. doi: 10.1016/j.bmcl.2016.11.022. Epub 2016 Nov 10.
2
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.通过虚拟筛选发现具有新型支架的组胺 H4 受体的纳摩尔配体。
Eur J Med Chem. 2017 Jan 5;125:565-572. doi: 10.1016/j.ejmech.2016.09.074. Epub 2016 Sep 24.
3
Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists.一类2-苯并噻唑基苯基甲基醚组胺H4受体拮抗剂的合成与评价
Bioorg Med Chem Lett. 2016 Nov 1;26(21):5263-5266. doi: 10.1016/j.bmcl.2016.09.049. Epub 2016 Sep 19.
4
Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine.鼓室内注射地塞米松加用高剂量倍他司汀治疗梅尼埃病
Am J Otolaryngol. 2016 May-Jun;37(3):225-30. doi: 10.1016/j.amjoto.2015.12.007. Epub 2015 Dec 30.
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Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.组胺H4受体激活增强变应性炎症：自然杀伤细胞在体内外的作用
J Dermatol Sci. 2016 Aug;83(2):106-15. doi: 10.1016/j.jdermsci.2016.04.011. Epub 2016 Apr 22.
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Histamine receptors.组胺受体
Neuropharmacology. 2016 Jul;106:1-2. doi: 10.1016/j.neuropharm.2016.04.007. Epub 2016 Apr 14.
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Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function.组胺H1和H4受体的联合阻断通过调节树突状细胞功能抑制花生诱导的肠道过敏反应。
Allergy. 2016 Nov;71(11):1561-1574. doi: 10.1111/all.12904. Epub 2016 Aug 3.
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Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞参与哮喘和过敏性疾病的生物标志物。
World Allergy Organ J. 2016 Feb 11;9:7. doi: 10.1186/s40413-016-0094-3. eCollection 2016.
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Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.嗜酸性气道炎症：在哮喘和慢性阻塞性肺疾病中的作用
Ther Adv Chronic Dis. 2016 Jan;7(1):34-51. doi: 10.1177/2040622315609251.
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Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.组胺H1受体在脑激活系统缺乏时对行为状态和觉醒维持的作用：一项使用基因敲除小鼠模型的研究
Neuropharmacology. 2016 Jul;106:20-34. doi: 10.1016/j.neuropharm.2015.12.014. Epub 2015 Dec 23.

New antihistamines - perspectives in the treatment of some allergic and inflammatory disorders.

作者信息

Tatarkiewicz Jan, Rzodkiewicz Przemysław, Żochowska Małgorzata, Staniszewska Anna, Bujalska-Zadrożny Magdalena

机构信息

Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.

Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

出版信息

Arch Med Sci. 2019 Mar;15(2):537-553. doi: 10.5114/aoms.2017.68534. Epub 2018 Feb 4.

DOI:10.5114/aoms.2017.68534
PMID:30899308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6425212/
Abstract
摘要