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应用胎儿心电图 ST 分析对高危分娩进行产时监测:一项 6010 例分娩的观察性研究。

Intrapartum monitoring of high-risk deliveries with ST analysis of the fetal electrocardiogram: an observational study of 6010 deliveries.

机构信息

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

出版信息

Acta Obstet Gynecol Scand. 2013 Jan;92(1):75-84. doi: 10.1111/j.1600-0412.2012.01528.x.

Abstract

OBJECTIVE

To evaluate the clinical use of ST analysis (STAN) for intrapartum monitoring of high-risk pregnancies.

DESIGN

Prospective observational study.

SETTING

University hospital, Norway, 2004-2008.

POPULATION

Singleton pregnancies with a gestational age above 35(+6) weeks.

METHODS

Analysis of maternal and neonatal outcomes for all deliveries according to the method of intrapartum monitoring.

MAIN OUTCOME MEASURES

Prevalence of cord metabolic acidosis (pH < 7.05, extracellular fluid base deficit (extracellular fluid) >12 mmol/L).

RESULTS

Of 23 203 deliveries, 6010 (25.9%) were monitored with STAN. Fetal blood sampling was performed in 146 (2.4%) of the 6010 cases. During the study period, the prevalence of cord metabolic acidosis and moderate cord acidosis (pH < 7.15) decreased in STAN-monitored deliveries from 1.4 to 0.3% (p = 0.01) and from 16.4 to 11.7% (p = 0.001), respectively. The prevalence of moderate and severe neonatal encephalopathy was 0.38%. In the birth population, the proportion of cesarean deliveries decreased from 10.1 to 8.8%. The risk of emergency cesarean section after STAN monitoring compared with those monitored with auscultation/cardiotocography was high (odds ratio 5.4, 95% confidence interval = 4.9-6.1) but remained stable during the study period.

CONCLUSIONS

ST analysis is a useful tool for identification of fetuses at risk of intrapartum hypoxia. Despite the restricted use of fetal blood sampling, we found a low proportion of cord metabolic acidosis and newborn morbidity.

摘要

目的

评估 ST 分析(STAN)在高危妊娠产时监测中的临床应用。

设计

前瞻性观察性研究。

地点

挪威大学医院,2004-2008 年。

人群

孕周大于 35(+6)周的单胎妊娠。

方法

根据产时监测方法分析所有分娩的母婴结局。

主要观察指标

脐带代谢性酸中毒(pH<7.05,细胞外液碱剩余(extracellular fluid)>12mmol/L)的发生率。

结果

在 23203 例分娩中,6010 例(25.9%)接受 STAN 监测。在这 6010 例患者中,有 146 例(2.4%)进行了胎儿血样采集。在研究期间,STAN 监测分娩中脐带代谢性酸中毒和中度脐带酸中毒(pH<7.15)的发生率从 1.4%降至 0.3%(p=0.01),从 16.4%降至 11.7%(p=0.001)。中度和重度新生儿脑病的发生率为 0.38%。在分娩人群中,剖宫产率从 10.1%降至 8.8%。与听诊/胎心监护相比,STAN 监测后的紧急剖宫产风险较高(优势比 5.4,95%置信区间=4.9-6.1),但在研究期间保持稳定。

结论

ST 分析是识别产时缺氧胎儿的有用工具。尽管胎儿血样采集的应用受限,但我们发现脐带代谢性酸中毒和新生儿发病率的比例较低。

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