小 GTP 酶 R-Ras 调节肿瘤血管的完整性和功能。
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
机构信息
Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827, USA.
出版信息
Cancer Cell. 2012 Aug 14;22(2):235-49. doi: 10.1016/j.ccr.2012.06.013.
Abstract
We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization.
摘要
我们证明，Ras 家族的小 GTPase R-Ras 对于肿瘤中成熟、功能正常的血管的形成至关重要。R-Ras 的基因缺失严重损害了小鼠肿瘤血管的成熟过程。相反，R-Ras 的功能获得改善了血管结构和血液灌注，并通过增强内皮屏障功能和周细胞与新生血管的关联来阻止血浆渗漏。因此，R-Ras 促进了肿瘤血管的正常化。这些发现表明，R-Ras 是肿瘤血管生成过程中血管完整性和功能的关键调节因子。
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