Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B-3000, Belgium.
Nature. 2011 May 19;473(7347):298-307. doi: 10.1038/nature10144.
Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms of angiogenesis (blood vessel growth) has increased at an explosive rate and has led to the approval of anti-angiogenic drugs for cancer and eye diseases. So far, hundreds of thousands of patients have benefited from blockers of the angiogenic protein vascular endothelial growth factor, but limited efficacy and resistance remain outstanding problems. Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
血管将氧气和营养物质输送到身体的各个部位，但也滋养着癌症等疾病。在过去的十年中，我们对血管生成（血管生长）分子机制的理解呈爆炸式增长，并已批准将抗血管生成药物用于癌症和眼部疾病。到目前为止，已有数十万患者受益于血管内皮生长因子等血管生成蛋白的抑制剂，但疗效有限和耐药性仍是突出问题。最近的临床前和临床研究表明了新的分子靶点和原理，这可能为提高抗血管生成策略的治疗效果提供途径。
