• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ral相互作用蛋白76和血管内皮生长因子在肿瘤及卵巢黄体微环境中血管生成的潜在作用

The potential role of Ral-interacting protein 76 and vascular endothelial growth factor on angiogenesis in the tumor and ovarian corpus luteum microenvironment.

作者信息

Lee Seunghyung

机构信息

College of Animal Life Sciences, Kangwon National University, Chuncheon, Republic of Korea.

出版信息

Transl Cancer Res. 2024 Oct 31;13(10):5702-5710. doi: 10.21037/tcr-24-770. Epub 2024 Oct 17.

DOI:10.21037/tcr-24-770
PMID:39525031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11543058/
Abstract

Tumors and the ovarian corpus luteum have complex mechanisms in the growth microenvironment. Angiogenesis is especially important for demonstrating the molecular mechanism of dynamic cellular function in tumors and corpus luteum. Angiogenesis in tumors and corpus luteum seems to have a similar function, and Ral-interacting protein 76 (RLIP76) and vascular endothelial growth factor (VEGF) are expressed in the tissues of tumors and ovarian corpus luteum. RLIP76 is a potential factor with VEGF in the tumor and corpus luteum angiogenesis. RLIP76 regulates a small GTPase (R-Ras) in cell survival, spreading, and migration. VEGF activates angiogenic functions in tumor and endothelial cells. Hypoxia-inducible factor-1 (HIF-1) is important in tumor growth, tumor angiogenesis, and corpus luteum. VEGF and HIF-1 regulate the angiogenic function of RLIP76, and RLIP76 controls vascular growth in endothelial and tumor cells. RLIP76, R-Ras, VEGF, and HIF-1 may be useful in the research of corpus luteum and cancer therapy and the study of mechanisms of tumor and corpus luteum angiogenesis. This review will help to elucidate the roles of RLIP76 and VEGF in tumor and corpus luteum angiogenesis, tumorigenesis, and the specific regulation of RLIP76 and VEGF. Thus, we reviewed the potential role of RLIP76 and VEGF in the angiogenesis of the tumor and corpus luteum in the tumor and ovarian microenvironment.

摘要

肿瘤和卵巢黄体在生长微环境中具有复杂的机制。血管生成对于阐明肿瘤和黄体中动态细胞功能的分子机制尤为重要。肿瘤和黄体中的血管生成似乎具有相似的功能，并且Ral相互作用蛋白76（RLIP76）和血管内皮生长因子（VEGF）在肿瘤组织和卵巢黄体中表达。RLIP76是肿瘤和黄体血管生成中与VEGF相关的一个潜在因子。RLIP76在细胞存活、扩散和迁移过程中调节一种小GTP酶（R-Ras）。VEGF激活肿瘤细胞和内皮细胞中的血管生成功能。缺氧诱导因子-1（HIF-1）在肿瘤生长、肿瘤血管生成和黄体中起重要作用。VEGF和HIF-1调节RLIP76的血管生成功能，而RLIP76控制内皮细胞和肿瘤细胞中的血管生长。RLIP76、R-Ras、VEGF和HIF-1可能在黄体研究、癌症治疗以及肿瘤和黄体血管生成机制的研究中具有应用价值。本综述将有助于阐明RLIP76和VEGF在肿瘤和黄体血管生成、肿瘤发生以及RLIP76和VEGF的具体调节中的作用。因此，我们综述了RLIP76和VEGF在肿瘤和卵巢微环境中肿瘤和黄体血管生成中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb53/11543058/f9de2ab5c2fe/tcr-13-10-5702-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb53/11543058/4bf943a6ec47/tcr-13-10-5702-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb53/11543058/f9de2ab5c2fe/tcr-13-10-5702-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb53/11543058/4bf943a6ec47/tcr-13-10-5702-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb53/11543058/f9de2ab5c2fe/tcr-13-10-5702-f2.jpg

相似文献

1
The potential role of Ral-interacting protein 76 and vascular endothelial growth factor on angiogenesis in the tumor and ovarian corpus luteum microenvironment.Ral相互作用蛋白76和血管内皮生长因子在肿瘤及卵巢黄体微环境中血管生成的潜在作用
Transl Cancer Res. 2024 Oct 31;13(10):5702-5710. doi: 10.21037/tcr-24-770. Epub 2024 Oct 17.
2
A potential function of RLIP76 in the ovarian corpus luteum.RLIP76 在卵巢黄体中的潜在功能。
J Ovarian Res. 2019 Apr 18;12(1):34. doi: 10.1186/s13048-019-0510-8.
3
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.RLIP76调节肿瘤细胞中的HIF-1活性、VEGF表达与分泌，以及内皮细胞的分泌组反式激活。
FASEB J. 2014 Sep;28(9):4158-68. doi: 10.1096/fj.14-255711. Epub 2014 Jun 13.
4
Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum.抑制灵长类动物卵巢中的血管内皮生长因子可上调卵泡和黄体中的缺氧诱导因子-1α。
Endocrinology. 2008 Jul;149(7):3313-20. doi: 10.1210/en.2007-1649. Epub 2008 Apr 3.
5
Angiogenesis in the corpus luteum.黄体中的血管生成。
Endocrine. 2000 Feb;12(1):1-9. doi: 10.1385/ENDO:12:1:1.
6
Effect of HIF-1a/VEGF signaling pathway on plasma progesterone and ovarian prostaglandin F₂a secretion during luteal development of pseudopregnant rats.缺氧诱导因子-1α/血管内皮生长因子信号通路对假孕大鼠黄体发育过程中血浆孕酮和卵巢前列腺素F₂α分泌的影响
Genet Mol Res. 2015 Aug 3;14(3):8796-809. doi: 10.4238/2015.August.3.3.
7
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.肺癌的新兴治疗方法——靶向RLIP76分子转运体
Lung Cancer (Auckl). 2013;2013(4):61-69. doi: 10.2147/LCTT.S53672.
8
[Contribution of Tissue Hypoxia to Corpus Luteum Formation].[组织缺氧对黄体形成的作用]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Dec 30;41(6):837-841. doi: 10.3881/j.issn.1000-503X.11142.
9
Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia.RLIP76 在缺氧条件下通过稳定 HIF-1α 促进胶质瘤细胞糖酵解和肿瘤发生中的关键作用。
Mol Neurobiol. 2022 Nov;59(11):6724-6739. doi: 10.1007/s12035-022-02999-w. Epub 2022 Aug 23.
10
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.RALBP1/RLIP76 缺失可通过抑制肿瘤新生血管生成抑制肿瘤生长。
Cancer Res. 2012 Oct 15;72(20):5165-73. doi: 10.1158/0008-5472.CAN-12-0468. Epub 2012 Aug 17.

本文引用的文献

1
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation.前扣带回皮层中的催产素通过抑制突触前长时程增强来减轻神经性疼痛和情绪焦虑。
Cell Rep. 2021 Jul 20;36(3):109411. doi: 10.1016/j.celrep.2021.109411.
2
Change of Ras and its guanosine triphosphatases (GTPases) during development and regression in bovine corpus luteum.牛黄体发育和退化过程中 Ras 及其鸟苷三磷酸酶（GTPases）的变化。
Theriogenology. 2020 Mar 1;144:16-26. doi: 10.1016/j.theriogenology.2019.12.014. Epub 2019 Dec 23.
3
Tumor Microenvironment and Cell Fusion.
肿瘤微环境与细胞融合。
Biomed Res Int. 2019 Jul 11;2019:5013592. doi: 10.1155/2019/5013592. eCollection 2019.
4
A potential function of RLIP76 in the ovarian corpus luteum.RLIP76 在卵巢黄体中的潜在功能。
J Ovarian Res. 2019 Apr 18;12(1):34. doi: 10.1186/s13048-019-0510-8.
5
The existence and potential of germline stem cells in the adult mammalian ovary.成年哺乳动物卵巢中生殖干细胞的存在和潜能。
Climacteric. 2019 Feb;22(1):22-26. doi: 10.1080/13697137.2018.1543264. Epub 2019 Jan 2.
6
MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells.miR-29b 影响 PROG 的分泌并促进牛黄体细胞的增殖。
PLoS One. 2018 Apr 4;13(4):e0195562. doi: 10.1371/journal.pone.0195562. eCollection 2018.
7
The Dynamics of microRNA Transcriptome in Bovine Corpus Luteum during Its Formation, Function, and Regression.牛黄体形成、功能及退化过程中微小RNA转录组的动态变化
Front Genet. 2017 Dec 15;8:213. doi: 10.3389/fgene.2017.00213. eCollection 2017.
8
Follicle vascularity coordinates corpus luteum blood flow and progesterone production.卵泡血管生成协调黄体血流和孕酮生成。
Reprod Fertil Dev. 2017 Mar;29(3):448-457. doi: 10.1071/RD15223.
9
RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.RLIP76通过Akt/mTOR信号通路增加胃癌细胞凋亡。
Oncol Rep. 2016 Oct;36(4):2216-24. doi: 10.3892/or.2016.5043. Epub 2016 Aug 25.
10
Expression and localization of angiopoietin family in corpus luteum during different stages of oestrous cycle and modulatory role of angiopoietins on steroidogenesis, angiogenesis and survivability of cultured buffalo luteal cells.发情周期不同阶段黄体中血管生成素家族的表达与定位以及血管生成素对水牛培养黄体细胞类固醇生成、血管生成和存活能力的调节作用
Reprod Domest Anim. 2016 Dec;51(6):855-869. doi: 10.1111/rda.12739. Epub 2016 Aug 28.