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2010-2011 年度甲型 H1N1pdm09 病毒所致流感症状严重程度增加但神经氨酸酶抑制剂效果不变：与前一季节以及季节性甲型 H3N2 和乙型流感的比较

Increased symptom severity but unchanged neuraminidase inhibitor effectiveness for A(H1N1)pdm09 in the 2010-2011 season: comparison with the previous season and with seasonal A(H3N2) and B.

机构信息

Japan Physicians Association, Tokyo Medical Association Building 3F, Tokyo, Japan.

出版信息

Influenza Other Respir Viruses. 2013 May;7(3):448-55. doi: 10.1111/j.1750-2659.2012.00421.x. Epub 2012 Aug 16.

DOI:10.1111/j.1750-2659.2012.00421.x
PMID:22897904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5779821/
Abstract

BACKGROUND

No studies of the clinical symptoms before starting therapy or of the effectiveness of neuraminidase inhibitors (NAIs) have been carried out of the 2009-2010 and 2010-2011 seasons that compare A(H1N1)pdm09 or the three circulating types of influenza virus.

METHODS

The clinical symptoms and duration of fever (body temperature ≥37·5°C) after the first dose of an NAI (oseltamivir, zanamivir, laninamivir) were analyzed. PCR was carried out for 365 patients with A(H1N1)pdm09 in the 2009-2010 season and for 388 patients with one of the three types of influenza circulating in the 2010-2011 season. IC50 for the three NAIs was also analyzed in 51 patients in the 2010-2011 season.

RESULTS

The peak body temperature was significantly higher in 2010-2011 than in 2009-2010 for patients under 20 years with A(H1N1)pdm09, and in the 2010-2011 season for children 15 years or younger with A(H1N1)pdm09 than for those with other virus types. The percentage of A(H1N1)pdm09 patients with loss of appetite or fatigue was significantly higher in 2010-2011 than in the previous season. The duration of fever was not affected by the kind of NAI or by age in multiple regression analysis. The percentage of patients afebrile at 48 hours after the first dose of NAI was significantly higher for A(H1N1)pdm09 than for A(H3N2) (laninamivir) or B (oseltamivir and laninamivir).

CONCLUSION

Although the clinical symptoms of A(H1N1)pdm09 were slightly more severe in the 2010-2011 season, the effectiveness of the NAIs remained high in comparison with 2009-2010 and with other types of seasonal influenza.

摘要

背景

在 2009-2010 年和 2010-2011 年季节中，尚无研究针对开始治疗前的临床症状或神经氨酸酶抑制剂（NAI）的有效性进行过比较，研究对象为 A(H1N1)pdm09 或三种流行的流感病毒。

方法

分析了首次使用 NAI（奥司他韦、扎那米韦、那拉米韦）后患者的临床症状和发热持续时间（体温≥37.5°C）。在 2009-2010 年季节中对 365 例 A(H1N1)pdm09 患者和 2010-2011 年季节中对 388 例三种流行流感病毒患者进行了 PCR 检测。还在 2010-2011 年季节中对 51 例患者分析了三种 NAI 的 IC50。

结果

2010-2011 年，20 岁以下 A(H1N1)pdm09 患者和 15 岁以下 A(H1N1)pdm09 患儿的峰值体温明显高于 2009-2010 年，2010-2011 年 A(H1N1)pdm09 患者食欲不振或疲劳的比例明显高于前一季节。在多元回归分析中，发热持续时间不受 NAI 种类或年龄的影响。首次使用 NAI 后 48 小时内无热患者的比例，A(H1N1)pdm09 明显高于 A(H3N2)（那拉米韦）或 B（奥司他韦和那拉米韦）。

结论

尽管 2010-2011 年 A(H1N1)pdm09 的临床症状略为严重，但与 2009-2010 年和其他季节性流感相比，NAI 的疗效仍然很高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/2578a028ab70/IRV-7-448-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/e8336518daca/IRV-7-448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/6a615b975f0c/IRV-7-448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/2578a028ab70/IRV-7-448-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/e8336518daca/IRV-7-448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/6a615b975f0c/IRV-7-448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee0c/5779821/2578a028ab70/IRV-7-448-g003.jpg

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本文引用的文献

1
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J Infect Chemother. 2012 Aug;18(4):529-33. doi: 10.1007/s10156-012-0377-8. Epub 2012 Feb 28.
2
Persistence of pandemic influenza H1N1 virus in young patients after oseltamivir therapy in the 2009-2010 season: a comparison with seasonal H1N1 with or without H275Y mutation.2009-2010 年季节性流感 H1N1 病毒在奥司他韦治疗后在年轻患者中的持续存在：与无 H275Y 突变或季节性 H1N1 的比较。
J Infect Chemother. 2012 Apr;18(2):180-6. doi: 10.1007/s10156-011-0314-2. Epub 2011 Dec 23.
3
2009 - 2012年南非流感病毒型别和亚型的流行病学情况
Emerg Infect Dis. 2014 Jul;20(7):1162-9. doi: 10.3201/eid2007.131869.
Mortality due to pandemic (H1N1) 2009 influenza in England: a comparison of the first and second waves.
英格兰 2009 年甲型 H1N1 流感大流行所致死亡率：第一波和第二波的比较。
Epidemiol Infect. 2012 Sep;140(9):1533-41. doi: 10.1017/S0950268811001968. Epub 2011 Nov 1.
4
The post-infection outcomes of influenza and acute respiratory infection in patients above 50 years of age in Japan: an observational study.日本 50 岁以上患者流感和急性呼吸道感染的感染后结局：一项观察性研究。
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5
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Euro Surveill. 2011 Jan 20;16(3):19772.
9
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J Infect Chemother. 2011 Jun;17(3):375-81. doi: 10.1007/s10156-010-0179-9. Epub 2010 Dec 1.
10
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Clin Infect Dis. 2010 Nov 15;51(10):1167-75. doi: 10.1086/656802. Epub 2010 Oct 11.