Department of Anesthesia, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Biomed Pharmacother. 2012 Oct;66(7):535-40. doi: 10.1016/j.biopha.2012.04.006. Epub 2012 May 20.
MiRNAs play an important role in regulating tumor migration and invasion, and abnormal expression of miRNAs occurs in various kinds of human cancers. In this essay, it is reported that the level of miRNA-218 decreases in metastatic breast cancer cells, moreover, miRNA-218 suppresses breast cancer cells migration and invasion through binding Robo1 (one of Slit receptors) to its 3'UTR. MiRNA-218 restoration suppresses Robo1 expression and inhibits breast cancer cells invasion and migration. What the results describe is that the function of Robo1 regulated by miRNA-218 may provide a new strategy for inhibiting migration and invasion of breast cancer cells.
miRNAs 在调控肿瘤迁移和侵袭方面发挥着重要作用，异常表达的 miRNAs 存在于各种人类癌症中。本文报道，miRNA-218 在转移性乳腺癌细胞中表达降低，miRNA-218 通过结合 Robo1（Slit 受体之一）的 3'UTR 抑制乳腺癌细胞迁移和侵袭。miRNA-218 的恢复可抑制 Robo1 的表达并抑制乳腺癌细胞的侵袭和迁移。结果表明，miRNA-218 调控 Robo1 的功能可能为抑制乳腺癌细胞迁移和侵袭提供新策略。
