Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Mayo Clinic 200 First Street SW, Rochester, Minnesota 55905, USA.
Pancreatology. 2012 Jul-Aug;12(4):289-94. doi: 10.1016/j.pan.2012.05.003. Epub 2012 May 11.
Autoimmune pancreatitis (AIP) has been classified into type 1 and type 2 subtypes. Serum immunoglobulin G4 (IgG4) elevation characterizes type 1 AIP. Type 2 AIP and a subset of type 1 AIP are seronegative, i.e., have normal serum IgG4 levels.
We compared the profiles of the three subsets of AIP to identify the unique characteristics of seronegative type 1 AIP and type 2 AIP.
We compared the clinical profiles of 69 seropositive type 1 AIP patients, 21 seronegative type 1 AIP patients and 22 type 2 AIP patients.
Among type 1 AIP, seronegative group had similar clinical profiles when compared to seropositive group except that they were more likely to undergo surgical resection than seropositive patients (p = 0.001). Seronegative type I AIP patients were older (61.9 ± 13.7 vs 45.3 ± 17.4; p = 0.004), and differed in the occurrence of other organ involvement (OOI) (71.4% vs 0%; p < 0.001) and disease relapse (33.3% vs 0%; p = 0.005) when compared with type 2 AIP. All seronegative type 1 AIP patients had at least one of the following -OOI, disease relapse, and age >50 years while none of the type 2 AIP had OOI or disease relapse.
Seronegative and seropositive type 1 AIP patients have similar clinical profiles, which are distinct from that of type 2 AIP. Among the seronegative AIP group, patients are more likely to have type 1 AIP rather than type 2 AIP if they are older than 50 years or have OOI or disease relapse.
自身免疫性胰腺炎（AIP）已分为 1 型和 2 型亚型。血清免疫球蛋白 G4（IgG4）升高是 1 型 AIP 的特征。2 型 AIP 和部分 1 型 AIP 为血清阴性，即 IgG4 水平正常。
我们比较了 AIP 的三个亚组的特征，以确定血清阴性 1 型 AIP 和 2 型 AIP 的独特特征。
我们比较了 69 例血清阳性 1 型 AIP 患者、21 例血清阴性 1 型 AIP 患者和 22 例 2 型 AIP 患者的临床特征。
在 1 型 AIP 中，血清阴性组与血清阳性组的临床特征相似，但与血清阳性患者相比，他们更有可能接受手术切除（p=0.001）。血清阴性 1 型 AIP 患者年龄较大（61.9±13.7 岁 vs 45.3±17.4 岁；p=0.004），且发生其他器官受累（OOI）（71.4% vs 0%；p<0.001）和疾病复发（33.3% vs 0%；p=0.005）的情况也不同。与 2 型 AIP 相比，所有血清阴性 1 型 AIP 患者至少有一种-OOI、疾病复发和年龄>50 岁，而没有 2 型 AIP 患者有 OOI 或疾病复发。
血清阴性和血清阳性 1 型 AIP 患者的临床特征相似，与 2 型 AIP 不同。在血清阴性 AIP 组中，如果患者年龄大于 50 岁或有 OOI 或疾病复发，则更有可能患有 1 型 AIP，而不是 2 型 AIP。
