Wang Puzi, Xie Rongli, Zhao Zhifeng, Ren Jiajun, Fei Jian
Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Medicine (Baltimore). 2018 Feb;97(8):e9982. doi: 10.1097/MD.0000000000009982.
Autoimmune pancreatitis is a form of chronic pancreatitis, characterized by diffused enlargement of the pancreas and irregular narrowing of the main pancreatic duct. The theory that portal hypertension is associated with autoimmune pancreatitis has not been emphasized. In addition, only a few studies report that the gastrointestinal tract hemorrhage caused by portal hypertension is associated with autoimmune pancreatitis.
The patient was a 61-year-old male with pancreas occupying lesion detected in a physical examination. Preoperative CT showed portal vein diameter increased significantly (1.6 cm) and the junction of splenic and portal vein was capsuled by lesions and the splenic vein became thin. The Whippie procedure was performed for the correction of the lesion. The pancreatic tissue showed chronic inflammation and lymphocytic infiltration and fibrosis, and abundant IgG4 cells. After the surgery, the patient suffered twice from postoperative hemorrhage (9 and 16 mos).
Postoperative hemorrhage, autoimmune pancreatitis.
Electronic gastroscopy, exploratory laparotomy, and titanium clips were used simultaneously to stop the bleeding.
The patient recovered well after the surgery.
In this study, we present the case of repeated postoperative hemorrhage (9 and 16 mos). We discussed the correlation between postoperative hemorrhage and autoimmune pancreatitis, and the cause of postoperative hemorrhage.
自身免疫性胰腺炎是一种慢性胰腺炎,其特征为胰腺弥漫性肿大及主胰管不规则狭窄。门静脉高压与自身免疫性胰腺炎相关的理论尚未得到重视。此外,仅有少数研究报道门静脉高压所致的胃肠道出血与自身免疫性胰腺炎有关。
该患者为61岁男性,体检时发现胰腺占位性病变。术前CT显示门静脉直径显著增宽(1.6厘米),脾静脉与门静脉交界处被病变包绕,脾静脉变细。行惠普尔手术以切除病变。胰腺组织显示慢性炎症、淋巴细胞浸润及纤维化,并有大量IgG4细胞。术后,患者发生两次术后出血(分别在术后9个月和16个月)。
术后出血,自身免疫性胰腺炎。
同时采用电子胃镜、剖腹探查及钛夹止血。
患者术后恢复良好。
在本研究中,我们报告了该患者术后反复出血(9个月和16个月)的病例。我们讨论了术后出血与自身免疫性胰腺炎之间的相关性以及术后出血的原因。