美沙酮中毒及对早产儿的可能诱导作用和增强消除。
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
出版信息
J Med Toxicol. 2012 Dec;8(4):432-5. doi: 10.1007/s13181-012-0249-8.
INTRODUCTION
Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate the management of methadone overdose in neonates, and literature involving methadone toxicokinetics and toxicodynamics in pediatric and neonate populations is largely limited.
CASE REPORT
The clinical course and pharmacologic data of a massive methadone overdose in a 20-day-old male neonate is described, and a contemporary review of developmental pharmacology is presented.
DISCUSSION
As clinicians continue to use methadone in neonates, they should be aware of the many significant peculiarities regarding its toxicology and pharmacology in that patient population.
简介
描述成人和儿科患者群体中出现美沙酮过量的报告并不少见。然而，在早产儿患者群体中，此类报告却很少见，尽管该人群中对美沙酮的使用仍在不断增加。由于与年龄相关的药代动力学差异使新生儿美沙酮过量的处理变得复杂，并且涉及儿科和新生儿人群中美沙酮毒代动力学和毒效动力学的文献在很大程度上受到限制。
病例报告
描述了一名 20 天大的男性新生儿出现大量美沙酮过量的临床经过和药物数据，并对发育药理学进行了当代综述。
讨论
随着临床医生继续在新生儿中使用美沙酮，他们应该意识到在该患者群体中，美沙酮的毒理学和药理学存在许多显著的特殊性。
Zotero 插件