幼儿意外摄入美沙酮后发生非酮症高血糖昏迷。

Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion.

作者信息

Tiras Sinan, Haas Vincent, Chevret Laurent, Decobert Marion, Buisine Anne, Devictor Denis, Durand Philippe, Tissières Pierre

机构信息

Intensive Care Unit, Department of Pediatrics, Bicetre Hospital, Le Kremlin-Bicêtre, France.

出版信息

Ann Emerg Med. 2006 Oct;48(4):448-51. doi: 10.1016/j.annemergmed.2006.02.023. Epub 2006 Apr 19.

DOI:10.1016/j.annemergmed.2006.02.023

PMID:16997682

Abstract

Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycemia and discuss the possible pathophysiologic mechanisms of an underrecognized symptom of opiate intoxication in young children.

摘要

美沙酮过量服用的情况随着成人阿片类药物替代疗法使用频率的增加而增多。虽然儿童意外美沙酮中毒很少见，但现在越来越多地被认识到。我们报告了3例幼儿意外美沙酮过量的病例，这些幼儿最初表现出与严重非酮症高血糖相关的中枢神经系统抑制，并讨论了幼儿阿片类药物中毒这一未被充分认识症状的可能病理生理机制。