Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Mod Pathol. 2012 Dec;25(12):1637-43. doi: 10.1038/modpathol.2012.129. Epub 2012 Aug 17.
CD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in a number of B cell lymphoproliferative disorders, including primary mediastinal large B cell lymphoma, but not diffuse large B cell lymphoma, based on a preliminary study. Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma. CD200 exhibits the greatest staining sensitivity of the markers studied: 94%, compared with CD23 (69%), MAL (86%), TRAF (86%), and REL (77%). It exhibits staining specificity of 93%, similar to that of CD23 (93%) and MAL (97%), and greater than that of TRAF (77%) and REL (83%). We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma.
CD200 是免疫球蛋白超家族的膜糖蛋白，在一些 B 细胞淋巴瘤中表达，包括原发性纵隔大 B 细胞淋巴瘤，但不包括弥漫性大 B 细胞淋巴瘤，这是初步研究的结果。在这里，我们比较了 CD200 与原发性纵隔大 B 细胞淋巴瘤的其他标志物，包括 MAL 和 CD23，在 35 例原发性纵隔大 B 细胞淋巴瘤和 30 例弥漫性大 B 细胞淋巴瘤的福尔马林固定、石蜡包埋组织切片中的表达。CD200 表现出最高的染色敏感性：94%，与 CD23（69%）、MAL（86%）、TRAF（86%）和 REL（77%）相比。它的染色特异性为 93%，与 CD23（93%）和 MAL（97%）相似，高于 TRAF（77%）和 REL（83%）。我们得出结论，CD200 是诊断原发性纵隔大 B 细胞淋巴瘤的一种实用且有用的标志物。
