Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Poland.
Phytother Res. 2013 Jul;27(7):986-92. doi: 10.1002/ptr.4822. Epub 2012 Aug 16.
Penta-O-galloyl-β-D-glucose (PGG) occurrs in high concentrations in medicinal herbs such as Rhus chinensis, Paeonia suffruticosa, Acer truncatum and Terminalia chebula, which demonstrate anti-inflammatory activity. We investigated the effect of PGG on stimulated and non-stimulated neutrophils in processes which included reactive oxygen species generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), β₂ integrin (CD11b) and L-selectin (CD62L) expression and apoptosis. In concentrations of 5 μM-20 μM, PGG demonstrated statistically significant inhibition of ROS generation, IL-8 secretion and β₂ integrin expression in stimulated neutrophils. The inhibition of L-selectin expression by PGG resulted in prevention in neutrophils' endothelial attachment. The result obtained may explain the anti-inflammatory activity of this compound and underline the contribution of PGG in the activity of PGG rich plant extracts.
五没食子酰葡萄糖（PGG）在药用植物中如盐肤木、牡丹皮、槭树和诃子中含量较高，具有抗炎活性。我们研究了 PGG 对刺激和非刺激中性粒细胞的影响，包括活性氧物种生成（ROS）、基质金属蛋白酶-9 和白细胞介素-8 分泌（IL-8）、β₂整合素（CD11b）和 L-选择素（CD62L）表达和细胞凋亡。在 5μM-20μM 浓度下，PGG 对刺激中性粒细胞中 ROS 生成、IL-8 分泌和 β₂整合素表达具有统计学显著抑制作用。PGG 抑制 L-选择素表达可防止中性粒细胞与内皮细胞黏附。研究结果可能解释了该化合物的抗炎活性，并强调了 PGG 在富含 PGG 的植物提取物活性中的作用。
