• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血红素加氧酶-1 阻断可消除调节性 T 细胞对妊娠的保护作用，并促进树突状细胞的成熟。

Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells.

机构信息

Department of Experimental Obstetrics and Gynaecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany.

出版信息

PLoS One. 2012;7(8):e42301. doi: 10.1371/journal.pone.0042301. Epub 2012 Aug 10.

DOI:10.1371/journal.pone.0042301
PMID:22900010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3416808/
Abstract

Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal pregnancy and protect fetal antigens from maternal effector cells. Their effect is associated with the up-regulation of tolerance-associated molecules at the fetal-maternal interface. Among these, Heme Oxygenase-1 (HO-1, coded by Hmox1) is of special importance as its blockage correlates with increased abortion rates and its up-regulation positively affects pregnancy outcome. Here, we aimed to investigate whether the protective effect of Treg is mediated by HO-1 in a mouse model. HO-1 blockage by Zinc Protoporhyrin (ZnPPIX) abrogated the protective effect of Treg transfer. We found that HO-1 is important in maintaining maternal dendritic cells (DCs) in an immature state, which contributes to the expansion of the peripheral Treg population. This brings to light one essential pathway through which Treg mediates the semi-allogeneic fetus tolerance.

摘要

调节性 T 细胞（Treg）在胎儿保护中发挥重要作用。它们在正常妊娠期间扩增，使胎儿抗原免受母体效应细胞的攻击。它们的作用与胎儿-母体界面上与耐受相关的分子的上调有关。在这些分子中，血红素加氧酶-1（HO-1，由 Hmox1 编码）尤为重要，因为其阻断与流产率增加相关，其上调对妊娠结局有积极影响。在这里，我们旨在研究 Treg 的保护作用是否通过 HO-1 在小鼠模型中介导。锌原卟啉（ZnPPIX）阻断 HO-1 可消除 Treg 转移的保护作用。我们发现 HO-1 对于维持母体树突状细胞（DC）处于未成熟状态很重要，这有助于外周 Treg 群体的扩增。这揭示了 Treg 介导半同种异体胎儿耐受的一个重要途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/8c68fcf53419/pone.0042301.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/2cd77e858e55/pone.0042301.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/56f8a2fd514c/pone.0042301.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/3b3c56f71c5c/pone.0042301.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/b2839a407677/pone.0042301.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/0c7201e9dc87/pone.0042301.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/fc26d146941a/pone.0042301.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/8c68fcf53419/pone.0042301.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/2cd77e858e55/pone.0042301.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/56f8a2fd514c/pone.0042301.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/3b3c56f71c5c/pone.0042301.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/b2839a407677/pone.0042301.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/0c7201e9dc87/pone.0042301.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/fc26d146941a/pone.0042301.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/607c/3416808/8c68fcf53419/pone.0042301.g007.jpg

相似文献

1
Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells.血红素加氧酶-1 阻断可消除调节性 T 细胞对妊娠的保护作用，并促进树突状细胞的成熟。
PLoS One. 2012;7(8):e42301. doi: 10.1371/journal.pone.0042301. Epub 2012 Aug 10.
2
PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model.PD-1 阻断而非 CTLA-4 阻断可消除调节性 T 细胞在妊娠小鼠模型中的保护作用。
Am J Reprod Immunol. 2009 Nov;62(5):283-92. doi: 10.1111/j.1600-0897.2009.00737.x.
3
Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1.血红素加氧酶-1通过上调叉头框蛋白3调节性T细胞、白细胞介素-10和膜结合转化生长因子-β1减轻卵清蛋白诱导的气道炎症。
Am J Pathol. 2007 Dec;171(6):1904-14. doi: 10.2353/ajpath.2007.070096. Epub 2007 Nov 8.
4
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.表达血红素加氧酶-1的树突状细胞促进Foxp3 +调节性T细胞分化并减轻小鼠模型中气道炎症的严重程度。
PLoS One. 2016 Dec 29;11(12):e0168919. doi: 10.1371/journal.pone.0168919. eCollection 2016.
5
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface.通过上调血红素加氧酶-1来防止流产与胎儿-母体界面处Bag-1和神经纤毛蛋白-1水平升高有关。
J Immunol. 2005 Oct 15;175(8):4875-85. doi: 10.4049/jimmunol.175.8.4875.
6
Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface.调节性T细胞在母胎界面诱导形成一种特殊的耐受微环境。
Eur J Immunol. 2006 Jan;36(1):82-94. doi: 10.1002/eji.200535428.
7
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.CD4+CD25+调节性T细胞的抑制作用取决于抗原呈递细胞中血红素加氧酶-1的表达。
Am J Pathol. 2008 Jul;173(1):154-60. doi: 10.2353/ajpath.2008.070963. Epub 2008 May 29.
8
Heme oxygenase-1-mediated CD4+CD25high regulatory T cells suppress allergic airway inflammation.血红素加氧酶-1介导的CD4+CD25高表达调节性T细胞抑制过敏性气道炎症。
J Immunol. 2006 Nov 1;177(9):5936-45. doi: 10.4049/jimmunol.177.9.5936.
9
MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice.miR-155 是调节性 T 细胞扩增所必需的，以介导小鼠妊娠耐受。
Mucosal Immunol. 2020 Jul;13(4):609-625. doi: 10.1038/s41385-020-0255-0. Epub 2020 Jan 27.
10
Editorial: Heme oxygenase-1 and dendritic cells: what else?社论：血红素加氧酶-1与树突状细胞：还有什么？
J Leukoc Biol. 2010 Feb;87(2):185-7. doi: 10.1189/jlb.0909636.

引用本文的文献

1
Pregnancy-acquired memory CD4 regulatory T cells improve pregnancy outcome in mice.孕期获得的记忆性CD4调节性T细胞可改善小鼠的妊娠结局。
Nat Commun. 2025 Jul 15;16(1):6522. doi: 10.1038/s41467-025-61572-w.
2
Regulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women.调节性B细胞在孕妇外周血中与调节性T细胞呈负相关，与细胞因子呈正相关。
Am J Reprod Immunol. 2025 Feb;93(2):e70027. doi: 10.1111/aji.70027.
3
Exploration of ferroptosis-related biomarkers with prognostic capability in RIF based on WGCNA.

本文引用的文献

1
Graft rejection - endogenous or allogeneic?移植物排斥 - 内源性还是同种异体？
Immunology. 2012 Jun;136(2):123-32. doi: 10.1111/j.1365-2567.2012.03560.x.
2
Heme oxygenase-1 expression in the ovary dictates a proper oocyte ovulation, fertilization, and corpora lutea maintenance.血红素加氧酶-1 在卵巢中的表达决定了适当的卵母细胞排卵、受精和黄体维持。
Am J Reprod Immunol. 2012 May;67(5):376-82. doi: 10.1111/j.1600-0897.2011.01096.x. Epub 2011 Dec 2.
3
Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide.
基于加权基因共表达网络分析（WGCNA）探索在反复种植失败（RIF）中具有预后能力的铁死亡相关生物标志物。
J Assist Reprod Genet. 2025 Mar;42(3):949-959. doi: 10.1007/s10815-024-03370-9. Epub 2024 Dec 23.
4
Revolutionized attitude toward recurrent pregnancy loss and recurrent implantation failure based on precision regenerative medicine.基于精准再生医学，对复发性流产和反复种植失败的态度发生了革命性变化。
Heliyon. 2024 Oct 18;10(20):e39584. doi: 10.1016/j.heliyon.2024.e39584. eCollection 2024 Oct 30.
5
Immunological Indicators of Recurrent Pregnancy Loss: A Mendelian Randomization Study.复发性妊娠丢失的免疫指标：一项孟德尔随机化研究。
Reprod Sci. 2024 Sep;31(9):2783-2793. doi: 10.1007/s43032-024-01555-2. Epub 2024 Apr 24.
6
Beneficial or detrimental activity of regulatory T cells, indoleamine 2,3-dioxygenase, and heme oxygenase-1 in the lungs is influenced by the level of virulence of strain infection.调节性 T 细胞、吲哚胺 2,3-双加氧酶和血红素加氧酶-1在肺部的有益或有害活性受菌株感染毒力水平的影响。
Front Cell Infect Microbiol. 2023 May 22;13:1105872. doi: 10.3389/fcimb.2023.1105872. eCollection 2023.
7
Regulatory T cells are paramount effectors in progesterone regulation of embryo implantation and fetal growth.调节性 T 细胞是孕激素调节胚胎着床和胎儿生长的主要效应因子。
JCI Insight. 2023 Jun 8;8(11):e162995. doi: 10.1172/jci.insight.162995.
8
Potential Biomarkers and Endometrial Immune Microenvironment in Recurrent Implantation Failure.反复种植失败中的潜在生物标志物和子宫内膜免疫微环境。
Biomolecules. 2023 Feb 21;13(3):406. doi: 10.3390/biom13030406.
9
Innate and Adaptive Immune Systems in Physiological and Pathological Pregnancy.生理和病理妊娠中的先天性和适应性免疫系统
Biology (Basel). 2023 Mar 3;12(3):402. doi: 10.3390/biology12030402.
10
Breast cancers co-opt normal mechanisms of tolerance to promote immune evasion and metastasis.乳腺癌利用正常的耐受机制促进免疫逃逸和转移。
Am J Physiol Cell Physiol. 2022 Nov 1;323(5):C1475-C1495. doi: 10.1152/ajpcell.00189.2022. Epub 2022 Oct 3.
血红素加氧酶-1 通过一氧化碳调控小鼠子宫内胎儿存活。
J Pathol. 2011 Oct;225(2):293-304. doi: 10.1002/path.2946. Epub 2011 Jul 8.
4
Pregnancy: tolerance and suppression of immune responses.妊娠：免疫反应的耐受与抑制。
Methods Mol Biol. 2011;677:397-417. doi: 10.1007/978-1-60761-869-0_25.
5
Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice.调节性 T 细胞对于同种异体小鼠的早期妊娠着床和维持是必要的，但对于晚期妊娠则不是必需的。
J Reprod Immunol. 2010 Jun;85(2):121-9. doi: 10.1016/j.jri.2010.02.006. Epub 2010 May 2.
6
Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity.关键进展：人类 CD4+T 细胞的血红素加氧酶 1 表达不足以使其获得免疫调节能力。
J Leukoc Biol. 2010 Feb;87(2):193-202. doi: 10.1189/jlb.0508280. Epub 2009 Oct 1.
7
Effect of heme oxygenase-1 deficiency on placental development.血红素加氧酶-1 缺乏对胎盘发育的影响。
Placenta. 2009 Oct;30(10):861-8. doi: 10.1016/j.placenta.2009.07.012. Epub 2009 Aug 21.
8
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.树突状细胞通过由半乳糖凝集素-1驱动的、涉及白细胞介素27和白细胞介素10的免疫调节回路向T细胞传递耐受性信号。
Nat Immunol. 2009 Sep;10(9):981-91. doi: 10.1038/ni.1772. Epub 2009 Aug 9.
9
Immunoregulatory effects of HO-1: how does it work?血红素加氧酶-1 的免疫调节作用：它是如何发挥作用的？
Curr Opin Pharmacol. 2009 Aug;9(4):482-9. doi: 10.1016/j.coph.2009.05.008. Epub 2009 Jul 6.
10
Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates.在啮齿动物和非人类灵长类动物中，耐受性树突状细胞通过血红素加氧酶-1积极抑制T细胞。
FASEB J. 2009 Sep;23(9):3070-7. doi: 10.1096/fj.08-128173. Epub 2009 May 6.