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基于精准再生医学,对复发性流产和反复种植失败的态度发生了革命性变化。

Revolutionized attitude toward recurrent pregnancy loss and recurrent implantation failure based on precision regenerative medicine.

作者信息

Motlagh Asghari Kimia, Novinbahador Tannaz, Mehdizadeh Amir, Zolfaghari Mohammadali, Yousefi Mehdi

机构信息

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

出版信息

Heliyon. 2024 Oct 18;10(20):e39584. doi: 10.1016/j.heliyon.2024.e39584. eCollection 2024 Oct 30.

Abstract

Traditional treatment strategies for recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) often result in limited success, placing significant emotional and financial burdens on couples. However, novel approaches such as diagnostic gene profiling, cell therapy, stem cell-derived exosome therapy, and pharmacogenomics offer promising, personalized treatments. Combining traditional treatments with precision and regenerative medicine may enhance the efficacy of these approaches and improve pregnancy outcomes. This review explores how integrating these strategies can potentially transform the lives of couples experiencing repeated pregnancy loss or implantation failure, providing hope for improved treatment success. Precision and regenerative medicine represent a new frontier for managing RPL and RIF, offering promising solutions.

摘要

复发性流产(RPL)和反复种植失败(RIF)的传统治疗策略往往成效有限,给夫妻双方带来了巨大的情感和经济负担。然而,诸如诊断基因谱分析、细胞疗法、干细胞衍生外泌体疗法和药物基因组学等新方法提供了有前景的个性化治疗方案。将传统治疗与精准医学和再生医学相结合,可能会提高这些方法的疗效并改善妊娠结局。本综述探讨了整合这些策略如何有可能改变经历反复流产或种植失败的夫妻的生活,为提高治疗成功率带来希望。精准医学和再生医学是管理RPL和RIF的新前沿,提供了有前景的解决方案。

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