Moretti D V, Zanetti O, Binetti G, Frisoni G B
Centro San Giovanni di Dio Fatebenefratelli, TRccs, 25125 Brescia, Italy.
Int J Alzheimers Dis. 2012;2012:917537. doi: 10.1155/2012/917537. Epub 2012 Jul 26.
We evaluated the relationship between brain rhythmicity and both the cerebrovascular damage (CVD) and amygdalohippocampal complex (AHC) atrophy, as revealed by scalp electroencephalography (EEG) in a cohort of subjects with mild cognitive impairment (MCI). All MCI subjects underwent EEG recording and magnetic resonance imaging. EEGs were recorded at rest. Relative power was separately computed for delta, theta, alpha1, alpha2, and alpha3 frequency bands. In the spectral band power the severity of CVD was associated with increased delta power and decreased alpha2 power. No association of vascular damage was observed with alpha3 power. Moreover, the theta/alpha1 ratio could be a reliable index for the estimation of the individual extent of CV damage. On the other side, the group with moderate hippocampal atrophy showed the highest increase of alpha2 and alpha3 power. Moreover, when the amygdalar and hippocampal volumes are separately considered, within amygdalohippocampal complex (AHC), the increase of theta/gamma ratio is best associated with amygdalar atrophy whereas alpha3/alpha2 ratio is best associated with hippocampal atrophy. CVD and AHC damages are associated with specific EEG markers. So far, these EEG markers could have a prospective value in differential diagnosis between vascular and degenerative MCI.
我们评估了轻度认知障碍（MCI）受试者队列中，头皮脑电图（EEG）所揭示的脑节律性与脑血管损伤（CVD）及杏仁核海马复合体（AHC）萎缩之间的关系。所有MCI受试者均接受了EEG记录和磁共振成像检查。EEG在静息状态下记录。分别计算了δ、θ、α1、α2和α3频段的相对功率。在频谱带功率方面，CVD的严重程度与δ功率增加和α2功率降低相关。未观察到血管损伤与α3功率之间存在关联。此外，θ/α1比值可能是评估个体CV损伤程度的可靠指标。另一方面，中度海马萎缩组的α2和α3功率增加最为明显。此外，当分别考虑杏仁核和海马体积时，在杏仁核海马复合体（AHC）内，θ/γ比值的增加与杏仁核萎缩最为相关，而α3/α2比值与海马萎缩最为相关。CVD和AHC损伤与特定的EEG标记物相关。到目前为止，这些EEG标记物在血管性和退行性MCI的鉴别诊断中可能具有前瞻性价值。
