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仅在具有较高的上α/低α脑电图频率功率比的轻度认知障碍受试者中，θ频率增加与局部脑血流量减少有关。

Increase of theta frequency is associated with reduction in regional cerebral blood flow only in subjects with mild cognitive impairment with higher upper alpha/low alpha EEG frequency power ratio.

作者信息

Moretti Davide V, Prestia Annapaola, Binetti Giuliano, Zanetti Orazio, Frisoni Giovanni B

机构信息

Alzheimer Unit, IRCCS San Giovanni di Dio Fatebenefratelli Brescia, Italy.

出版信息

Front Behav Neurosci. 2013 Dec 5;7:188. doi: 10.3389/fnbeh.2013.00188. eCollection 2013.

DOI:10.3389/fnbeh.2013.00188
PMID:24367305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3851738/
Abstract

BACKGROUND

Several biomarkers have been proposed for detecting Alzheimer's disease (AD) in its earliest stages, that is, in the predementia stage. In an attempt to find noninvasive biomarkers, researchers have investigated the feasibility of neuroimaging tools, such as MRI, SPECT as well as neurophysiological measurements using EEG. Moreover, the increase of EEG alpha3/alpha2 frequency power ratio has been associated with AD-converters subjects with mild cognitive impairment (MCI).

OBJECTIVE

To study the association of alpha3/alpha2 frequency power ratio with regional cerebral blood flow (rCBF) changes in subjects with MCI.

METHODS

Twenty-seven adult subjects with MCI underwent EEG recording and perfusion single-photon emission computed tomography (SPECT) evaluation. The alpha3/alpha2 frequency power ratio was computed for each subject. Two groups were obtained according to the median values of alpha3/alpha2, at a cut-off of 1.17. Correlation between brain perfusion and EEG markers were detected.

RESULTS

Subjects with higher alpha3/alpha2 frequency power ratio showed a constant trend to a lower perfusion than low alpha3/alpha2 group. The two groups were significantly different as about the hippocampal volume and correlation with the theta frequency activity.

CONCLUSION

There is a complex interplay between cerebral blood flow, theta frequency activity, and hippocampal volume in MCI patients with prodromal Alzheimer's disease, characterized by higher EEG alpha3/alpha2 frequency power ratio.

摘要

背景

已经提出了几种生物标志物用于在阿尔茨海默病（AD）的最早阶段，即痴呆前阶段进行检测。为了寻找非侵入性生物标志物，研究人员研究了神经成像工具（如MRI、SPECT）以及使用脑电图（EEG）进行神经生理学测量的可行性。此外，EEG的α3/α2频率功率比的增加与轻度认知障碍（MCI）的AD转化者相关。

目的

研究MCI患者中α3/α2频率功率比与局部脑血流量（rCBF）变化之间的关联。

方法

27名成年MCI患者接受了脑电图记录和灌注单光子发射计算机断层扫描（SPECT）评估。计算每个受试者的α3/α2频率功率比。根据α3/α2的中位数，以1.17为临界值分为两组。检测脑灌注与EEG标志物之间的相关性。

结果

α3/α2频率功率比高的受试者与低α3/α2组相比，灌注呈持续降低趋势。两组在海马体积以及与θ频率活动的相关性方面存在显著差异。

结论

在以较高EEGα3/α2频率功率比为特征的前驱性阿尔茨海默病的MCI患者中，脑血流量、θ频率活动和海马体积之间存在复杂的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/8639132d6211/fnbeh-07-00188-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/e92c3bbbf00e/fnbeh-07-00188-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/39cff9c96889/fnbeh-07-00188-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/d426c6c3c4a9/fnbeh-07-00188-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/e789031525b3/fnbeh-07-00188-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/8639132d6211/fnbeh-07-00188-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/e92c3bbbf00e/fnbeh-07-00188-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/39cff9c96889/fnbeh-07-00188-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/d426c6c3c4a9/fnbeh-07-00188-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/e789031525b3/fnbeh-07-00188-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1f/3851738/8639132d6211/fnbeh-07-00188-g0005.jpg

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