Dhingra Sanjiv, Singh Uma, Bansal M P
Department of Biophysics, Panjab University, Chandigarh 160 014, India.
Indian J Biochem Biophys. 2003 Aug;40(4):260-4.
The effect of high fat diet (HFD) on thyroid hormones (T3/T4) and protective role of selenium (Se) were studied in rats. Se levels in serum and liver decreased significantly, whereas glutathione peroxidase (GSH-Px) in liver and lipid levels (cholesterol and triglycerides) in serum increased after 1, 2 and 3 months of HFD feeding in comparison to controls in all the three Se status i.e. deficient (0.02 ppm), adequate (0.2 ppm) and excess (1 ppm) groups. Levels of T3/T4 decreased significantly on HFD feeding, as compared to respective controls in all the groups. Within the deficient group, as Se deficiency progressed, T3/T4 levels decreased after 2 and 3 months in comparison to 1 month. A significant increase was observed in T3/T4 concentration on feeding 1 ppm (excess) Se supplemented diet, in comparison to adequate group. Also, in 1 ppm Se supplemented group as the Se deposition increased i.e. after 2 and 3 months, levels of T3/T4 increased significantly. So, the present study indicates that Se supplementation up to 1 ppm normalizes the T3 and T4 concentrations or regulates the hypothyroidism induced by hyperlipidemia.
研究了高脂饮食（HFD）对大鼠甲状腺激素（T3/T4）的影响以及硒（Se）的保护作用。在所有三种硒状态（即缺乏组（0.02 ppm）、充足组（0.2 ppm）和过量组（1 ppm））下，与对照组相比，高脂饮食喂养1、2和3个月后，血清和肝脏中的硒水平显著降低，而肝脏中的谷胱甘肽过氧化物酶（GSH-Px）和血清中的脂质水平（胆固醇和甘油三酯）升高。与所有组的各自对照组相比，高脂饮食喂养后T3/T4水平显著降低。在缺乏组中，随着硒缺乏的进展，与1个月相比，2个月和3个月后T3/T4水平降低。与充足组相比，喂食1 ppm（过量）硒补充饮食后，T3/T4浓度显著增加。此外，在1 ppm硒补充组中，随着硒沉积增加，即2个月和3个月后，T3/T4水平显著增加。因此，本研究表明，补充高达1 ppm的硒可使T3和T4浓度正常化或调节高脂血症诱导的甲状腺功能减退。
