Bhalla Sonali, Kaur Kamaljit, Mahmood Akhtar, Mahmood Safrun
Department of Biochemistry, Panjab University.
Indian J Biochem Biophys. 2004 Apr-Jun;41(2-3):116-9.
Effect of prenatal ethanol exposure has been studied on microvillus membrane glycosylation in developing rat intestine. In utero ethanol administration did not affect the gestation period but reduced litter size in ethanol-exposed group. Body weight, intestinal length and weight of pups born to ethanol-exposed rats during gestation, aged 4 to 30 days were significantly low compared to the respective controls. Total hexoses (p < 0.05) and sialic acid (p < 0.05, p < 0.01) contents of purified brush border membranes increased in pups exposed to ethanol prenatally, while the fucose content showed significant (p < 0.05, p < 0.01) decrease. The fucose-sialic acid molar ratio was also low in all age-groups of prenatally ethanol-exposed pups, compared to respective controls. The results indicate that ethanol ingestion during gestation alters the glycosylation pattern of intestine in rats, which may impair its functions during postnatal development.
已对孕期乙醇暴露对发育中大鼠肠道微绒毛膜糖基化的影响进行了研究。子宫内给予乙醇不影响妊娠期，但乙醇暴露组的窝仔数减少。与各自的对照组相比，妊娠期暴露于乙醇的大鼠所产4至30日龄幼崽的体重、肠道长度和重量显著较低。产前暴露于乙醇的幼崽中，纯化刷状缘膜的总己糖（p<0.05）和唾液酸（p<0.05，p<0.01）含量增加，而岩藻糖含量显著降低（p<0.05，p<0.01）。与各自的对照组相比，产前暴露于乙醇的幼崽所有年龄组的岩藻糖-唾液酸摩尔比也较低。结果表明，妊娠期摄入乙醇会改变大鼠肠道的糖基化模式，这可能会损害其出生后发育过程中的功能。
