Usuda K, Saito Y, Aikawa H, Sakurada A, Chen Y, Takahashi S, Kanma K, Sato M, Sagawa M, Fujimura S
Department of Thoracic Surgery, Tohoku University, Sendai, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Apr;42(4):486-91.
A total of 65 resected cases with primary lung cancer were examined on correlation between nuclear DNA content by flow cytometry and other prognostic factors, including tumor doubling time (DT). 1) DNA diploidy was found in 18 cases (28%) and DNA aneuploidy in 47 cases (72%). Percent aneuploidy was 79.5% in cases with adenocarcinoma, which tended to be higher than that in cases with squamous cell carcinoma (57.1%). 2) Percent aneuploidy in cases with advanced carcinomas tended to be higher than that in cases with earlier carcinomas, and percent aneuploidy in cases with rapid growing carcinomas tended to be higher than that in cases with slow growing carcinomas. 3) The geometric mean of DT of DNA aneuploid tumor was 130.0 day, which tended to be shorter than that of DNA diploid tumor (171.9 days), but the difference was not significant. There was not a significant correlation between DT and DNA Index. 4) The five-year survival rate of 47 patients with DNA aneuploid tumor was 45%, which was significantly lower than that of 18 patients with DNA diploid tumor (78%).
对65例原发性肺癌切除病例进行了流式细胞术检测核DNA含量与其他预后因素（包括肿瘤倍增时间（DT））之间的相关性研究。1）18例（28%）为DNA二倍体，47例（72%）为DNA非整倍体。腺癌病例中非整倍体百分比为79.5%，往往高于鳞状细胞癌病例（57.1%）。2）晚期癌病例的非整倍体百分比往往高于早期癌病例，生长快速的癌病例的非整倍体百分比往往高于生长缓慢的癌病例。3）DNA非整倍体肿瘤的DT几何平均值为130.0天，往往短于DNA二倍体肿瘤（171.9天），但差异不显著。DT与DNA指数之间无显著相关性。4）47例DNA非整倍体肿瘤患者的五年生存率为45%，显著低于18例DNA二倍体肿瘤患者（78%）。
