Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland.
Scand J Clin Lab Invest. 2012 Sep;72(5):395-402. doi: 10.3109/00365513.2012.687759.
Obesity and ectopic fat deposition are major risk factors for many diseases ranging from insulin resistance to type 2 diabetes and atherosclerosis. In obese individuals, the size of muscle fibers is increased mainly because of the ectopic fat present in skeletal muscle. The aim of the study was to investigate if adipokines would associate with muscle fiber characteristics and if muscle fiber characteristics and expression of the skeletal muscle adiponectin receptor (ADIPOR) would be associated with overweight and other components of the metabolic syndrome. This is a population-based, epidemiological cross-sectional study where normotensive, non-smoking men with normal OGTT provided a muscle biopsy (N = 54). Body mass index was higher in the group with the largest muscle fiber size (p for trend < 0.05) compared to medium (p < 0.05) or small (p < 0.05) muscle fiber size. Plasma adiponectin level (p < 0.05) was negatively and concentrations of leptin (p < 0.05) and hs-CRP (p < 0.05) positively associated with muscle fiber size before adjustments. The inverse association between the plasma adiponectin level and muscle fiber size tertile remained significant (p < 0.05) when adjusted for age and total adiposity. No associations were observed between the expression of muscle adiponectin receptors (ADIPOR) and features of the metabolic syndrome. Skeletal muscle fiber characteristics are related to overweight. In addition, a correlation was observed between low adiponectin and large muscle fiber size and this was not dependent on the amount of total fatness.
肥胖和异位脂肪沉积是许多疾病的主要危险因素，范围从胰岛素抵抗到 2 型糖尿病和动脉粥样硬化。在肥胖个体中，肌肉纤维的大小增加主要是由于骨骼肌中的异位脂肪。本研究旨在探讨脂肪因子是否与肌肉纤维特征相关，以及肌肉纤维特征和骨骼肌脂联素受体 (ADIPOR) 的表达是否与超重和代谢综合征的其他成分相关。这是一项基于人群的、横断面的流行病学研究，其中血压正常、不吸烟、OGTT 正常的男性提供了肌肉活检 (N = 54)。与中 (p < 0.05) 或小 (p < 0.05) 肌肉纤维大小相比，具有最大肌肉纤维大小的组的体重指数更高 (p 趋势 < 0.05)。调整前，血浆脂联素水平 (p < 0.05) 与肌肉纤维大小呈负相关，瘦素 (p < 0.05) 和 hs-CRP (p < 0.05) 浓度与肌肉纤维大小呈正相关。调整年龄和总肥胖度后，血浆脂联素水平与肌肉纤维大小三分位的负相关仍然显著 (p < 0.05)。肌肉脂联素受体 (ADIPOR) 的表达与代谢综合征的特征之间没有观察到相关性。骨骼肌纤维特征与超重有关。此外，还观察到低脂联素与大肌肉纤维大小之间存在相关性，而这与总肥胖程度无关。
