Babu Spoorthy N, Chetal Gaurav, Kumar Sudhir
IGNOU-I2IT Centre of Excellence for Advanced Education and Research, Pune, Maharashtra, India.
Asian Pac J Cancer Prev. 2012;13(5):1737-44. doi: 10.7314/apjcp.2012.13.5.1737.
Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation, immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis, adherence and motility. Of late, MIF is implicated in almost all stages of neoplasia and expression is a feature of most types of cancer. The presence of MIF in almost all tumors and all stages of cancer makes it an interesting candidate for cancer therapy. This review explores the roles of MIF in neoplasia.
巨噬细胞移动抑制因子（MIF）是一种多能细胞因子，在炎症、免疫反应和癌症发展中发挥作用。它协助巨噬细胞执行吞噬、黏附和移动等功能。近来，MIF几乎涉及肿瘤形成的所有阶段，且其表达是大多数癌症类型的一个特征。MIF存在于几乎所有肿瘤及癌症的各个阶段，这使其成为癌症治疗中一个引人关注的候选对象。本综述探讨了MIF在肿瘤形成中的作用。
