Wu Yong, Liu Yanjun, Dong Yunzhou, Vadgama Jay
Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, USA.
David Geffen School of Medicine, University of California, Los Angeles, USA.
Integr Cancer Sci Ther. 2016 Feb;3(1):370-378. doi: 10.15761/ICST.1000173. Epub 2016 Feb 15.
Epidemiological data demonstrate that patients with diabetes have an augmented risk of developing various types of cancers, accompanied by higher mortality. A number of mechanisms for this connection have been hypothesized, such as insulin resistance, hyperinsulinemia, hyperglycemia, and increased inflammatory processes. Apart from these potential mechanisms, several diabetes-associated dysregulated cytokines might be implicated in the link between diabetes and cancer. In fact, some inflammatory cytokines, e.g. TNF-α, IL-6 and leptin, have been revealed to play important roles in both initiation and progression of tumor. Here, we depict the role of these cytokines in key events of carcinogenesis and cancer development, including their capability to induce oxidative stress, inflammation, their participation in epithelial mesenchymal transition (EMT), angiogenesis, and metastasis. Finally, we will also highlight the existing knowledge in terms of the involvement of these cytokines in different cancer types and comment on potential significances for future clinical applications.
流行病学数据表明，糖尿病患者患各类癌症的风险增加，死亡率也更高。关于这种关联的机制有多种假说，如胰岛素抵抗、高胰岛素血症、高血糖以及炎症过程增加。除了这些潜在机制外，一些与糖尿病相关的细胞因子失调可能也与糖尿病和癌症之间的联系有关。事实上，一些炎性细胞因子，如肿瘤坏死因子-α、白细胞介素-6和瘦素，已被证明在肿瘤的发生和发展中都起着重要作用。在此，我们描述这些细胞因子在致癌作用和癌症发展的关键事件中的作用，包括它们诱导氧化应激、炎症的能力，它们参与上皮-间质转化（EMT）、血管生成和转移的情况。最后，我们还将强调关于这些细胞因子在不同癌症类型中的作用的现有知识，并对其未来临床应用的潜在意义进行评论。
