Mittal Ankush, Poudel Bibek, Pandeya Dipendra Raj, Gupta Satrudhan Pd, Sathian Brijesh, Yadav Shambhu Kumar
Department of Biochemistry, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Asian Pac J Cancer Prev. 2012;13(5):2253-5. doi: 10.7314/apjcp.2012.13.5.2253.
The objective of our present study was to assess the role of serum amyloid A (SAA) in stages and prognosis of renal cell carcinoma.
It was a hospital based retrospective study carried out in the Department of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between 1st January 2008 and 31st December 2011. The variables collected were SAA, CRP. Approval for the study was obtained from the institutional research ethical committee. Quantitative analysis of human SAA and C-reactive protein (CRP) was performed by radial immune diffusion (RID) assay for all cases.
Of the 422 total cases of renal cell carcinoma, 218 patients had normal and 204 abnormal SAA. SAA levels were grossly elevated in T3 stage (122.3±SD35.7) when compared to the mean for the T2 stage (84.2±SD24.4) (p value: 0.0001). Similarly, SAA levels were grossly elevated in M1 stage (190.0±SD12.7) when compared to the M0 stage (160.9±SD24.8) (p: 0.0001). There was no significant association with elevated CRP levels (209.1±SD22.7, normal 199.0±SD19.5) .
The validity of SAA in serum as being of independent prognostic significance in RCC was demonstrated with higher levels in advanced stage disease.
本研究的目的是评估血清淀粉样蛋白A（SAA）在肾细胞癌分期及预后中的作用。
这是一项基于医院的回顾性研究，于2008年1月1日至2011年12月31日在尼泊尔博卡拉马尼帕尔教学医院的内科和生物化学科进行。收集的变量包括SAA、CRP。本研究获得了机构研究伦理委员会的批准。对所有病例采用放射免疫扩散（RID）法对人SAA和C反应蛋白（CRP）进行定量分析。
在422例肾细胞癌患者中，218例患者的SAA正常，204例异常。与T2期平均值（84.2±标准差24.4）相比，T3期SAA水平显著升高（122.3±标准差35.7）（p值：0.0001）。同样，与M0期（160.9±标准差24.8）相比，M1期SAA水平显著升高（190.0±标准差12.7）（p：0.0001）。CRP水平升高（209.1±标准差22.7，正常为199.0±标准差19.5）与之无显著相关性。
血清SAA在肾细胞癌中具有独立预后意义，在晚期疾病中水平较高，证明了其有效性。
