Gudmundsson S, Steinsson K
Department of Internal Medicine, Landspitalinn University Hospital, Reykjavik, Iceland.
J Rheumatol. 1990 Sep;17(9):1162-7.
In a nationwide study the 1982 revised ARA criteria were applied for the classification of systemic lupus erythematosus (SLE). This unselected group of patients included all cases diagnosed and managed in hospitals, as well as outside hospitals in Iceland over the 10-year period from 1975 to 1984. Seventy-six new cases were found, with an incidence of 5.9 and 0.8/100,000 for females and males at risk, respectively. The mean age at diagnosis was 46.6 years. Twenty-five percent of the patients would have been missed had the study included hospital patients only. A clinical pattern different from previous studies was found as illustrated by a low incidence of kidney disease; nephritis was found in 20% of patients. Comparison with a former study on SLE in Iceland shows an actual increase in incidence over a period of 10 years. The 5 year survival was 84% and the 10 year survival 78%.
在一项全国性研究中，采用1982年修订的美国风湿病学会（ARA）标准对系统性红斑狼疮（SLE）进行分类。该未经过挑选的患者群体包括1975年至1984年这10年间在冰岛医院内以及医院外诊断和治疗的所有病例。共发现76例新病例，处于风险中的女性和男性发病率分别为5.9/10万和0.8/10万。诊断时的平均年龄为46.6岁。如果该研究仅纳入住院患者，那么25%的患者将会被漏诊。研究发现了一种与以往研究不同的临床模式，例如肾脏疾病的发病率较低；仅20%的患者发现有肾炎。与冰岛之前一项关于SLE的研究相比，发病率在10年期间实际有所增加。5年生存率为84%，10年生存率为78%。
