Jarukitsopa Sudumpai, Hoganson Deana D, Crowson Cynthia S, Sokumbi Olayemi, Davis Mark D, Michet Clement J, Matteson Eric L, Maradit Kremers Hilal, Chowdhary Vaidehi R
Bumrungrad Hospital, Bangkok, Thailand.
Mercy Arthritis & Osteoporosis Center, Des Moines, Iowa.
Arthritis Care Res (Hoboken). 2015 May;67(6):817-28. doi: 10.1002/acr.22502.
Epidemiologic studies comparing the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE) are few. Olmsted County, Minnesota provides a unique setting for such a study owing to resources of the Rochester Epidemiology Project. We sought to describe and compare the incidence and prevalence of SLE and CLE from 1993-2005.
SLE cases were identified from review of medical records and fulfilled the 1982 American College of Rheumatology classification criteria. CLE cases included patients with classic discoid lupus erythematosus, subacute CLE, lupus panniculitis, and bullous lupus erythematosus. Age- and sex-adjusted incidence and prevalence were standardized to the 2000 US white population.
The age- and sex-adjusted incidence of SLE (2.9 per 100,000; 95% confidence interval [95% CI] 2.0-3.7) was similar to that of CLE (4.2 per 100,000; 95% CI 3.1-5.2, P = 0.10). However, the incidence of CLE was 3 times higher than SLE in men (2.4 versus 0.8 per 100,000; P = 0.009). The age- and sex-adjusted prevalence of CLE on January 1, 2006 was higher than that of SLE (70.4 versus 30.5 per 100,000; P < 0.001). The prevalences of CLE and SLE in women were similar, but the prevalence of CLE was higher in men than in women (56.9 versus 1.6 per 100,000; P < 0.001). The incidence of CLE rose steadily with age and peaked at 60-69 years.
The incidences of CLE and SLE are similar, but CLE is more common than SLE in men and in older adults. These findings may reflect differences in genetic or environmental etiology of CLE.
比较系统性红斑狼疮（SLE）和孤立性皮肤红斑狼疮（CLE）发病率及患病率的流行病学研究较少。由于罗切斯特流行病学项目的资源，明尼苏达州奥尔姆斯特德县为开展此类研究提供了独特的条件。我们试图描述并比较1993年至2005年期间SLE和CLE的发病率及患病率。
通过查阅病历确定SLE病例，并符合1982年美国风湿病学会分类标准。CLE病例包括典型盘状红斑狼疮、亚急性CLE、狼疮性脂膜炎和大疱性红斑狼疮患者。年龄和性别调整后的发病率及患病率以2000年美国白种人群为标准进行标准化。
年龄和性别调整后的SLE发病率（每10万人中2.9例；95%置信区间[95%CI]2.0 - 3.7）与CLE发病率（每10万人中4.2例；95%CI 3.1 - 5.2，P = 0.10）相似。然而，男性中CLE的发病率比SLE高3倍（每10万人中2.4例对0.8例；P = 0.009）。2006年1月1日年龄和性别调整后的CLE患病率高于SLE（每10万人中70.4例对30.5例；P < 0.001）。CLE和SLE在女性中的患病率相似，但男性中CLE的患病率高于女性（每10万人中56.9例对1.6例；P < 0.001）。CLE的发病率随年龄稳步上升，在60 - 69岁达到峰值。
CLE和SLE的发病率相似，但在男性和老年人中CLE比SLE更常见。这些发现可能反映了CLE在遗传或环境病因方面的差异。
