Department of Neurology, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Neurobiol Aging. 2013 Jan;34(1):100-9. doi: 10.1016/j.neurobiolaging.2012.07.014. Epub 2012 Aug 15.
We assessed midlife blood pressure (BP), body mass index, total cholesterol, and their changes over time in relation to cortical thickness on magnetic resonance imaging 28 years later in 63 elderly at risk of dementia. Participants in the population-based Cardiovascular Risk Factors, Aging, and Dementia study were first examined at midlife. A first follow-up was conducted after 21 years, and a second follow-up after an additional 7 years. Magnetic resonance images from the second follow-up were analyzed using algorithms developed at McGill University, Montreal, Canada. Midlife hypertension was related to thinner cortex in several brain areas, including insular, frontal, and temporal cortices. In elderly with thinner insular cortex, there was a continuous decline in systolic BP and an increase in pulse pressure after midlife, while in elderly with thicker insular cortex the decline in systolic BP started at older ages, paralleled by a decline in pulse pressure. No associations were found between body mass index, cholesterol, or apolipoprotein E ε4 allele and cortical thickness in this group of elderly at risk individuals.
我们评估了中年时的血压（BP）、体重指数、总胆固醇及其随时间的变化与 28 年后 63 名痴呆高危老年人磁共振成像上皮质厚度的关系。该人群基础心血管风险因素、衰老和痴呆研究中的参与者首先在中年时接受检查。21 年后进行了第一次随访，另外 7 年后进行了第二次随访。使用加拿大蒙特利尔麦吉尔大学开发的算法分析了第二次随访的磁共振图像。中年高血压与包括岛叶、额叶和颞叶在内的多个脑区的皮质变薄有关。在皮质岛叶较薄的老年人中，从中年后收缩压持续下降，脉压增加，而在皮质岛叶较厚的老年人中，收缩压的下降始于老年，同时脉压下降。在这群有痴呆风险的老年人中，体重指数、胆固醇或载脂蛋白 E ε4 等位基因与皮质厚度之间没有关联。
