Sindi Shireen, Kåreholt Ingemar, Spulber Gabriela, Soininen Hilkka, Kivipelto Miia, Solomon Alina
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden.
J Alzheimers Dis Rep. 2017 Dec 2;1(1):219-227. doi: 10.3233/ADR-170035.
Work-related stress has been associated with an increased dementia risk. However, less is known about the mechanisms that underlie these associations.
The goal is to examine associations between midlife work-related stress and late-life structural brain alterations.
The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study participants were randomly selected from independent population-based surveys (mean age 50) in Finland. MRI measurements included gray matter (GM) volume, white matter lesions (WML) and medial temporal atrophy (MTA) (1st re-examination, = 102); and GM volume, hippocampal volume, WML volume, cortical thickness, and MTA (2nd re-examination, = 64). Work-related stress comprised a score from two questions administered in midlife.
Higher levels of midlife work-related stress were associated with lower GM volume (β= -0.077, = 0.033) at the first re-examination, even after adjusting for several confounders. No significant associations were found with MTA, WML, or MRI measurements at the second re-examination.
Previously shown associations of midlife work-related stress with dementia risk may be at least partly explained by associations with lower GM volume in late-life. The lack of associations at the second re-examination may indicate a critical time window for the effects of midlife work-related stress, and/or selective survival/participation.
工作相关压力与痴呆风险增加有关。然而，对于这些关联背后的机制了解较少。
目的是研究中年工作相关压力与晚年脑结构改变之间的关联。
心血管危险因素、衰老与痴呆（CAIDE）研究参与者从芬兰基于独立人群的调查（平均年龄50岁）中随机选取。MRI测量包括灰质（GM）体积、白质病变（WML）和内侧颞叶萎缩（MTA）（首次复查，n = 102）；以及GM体积、海马体积、WML体积、皮质厚度和MTA（第二次复查，n = 64）。工作相关压力由中年时提出的两个问题的得分组成。
在首次复查时，即使在调整了几个混杂因素后，较高水平的中年工作相关压力与较低的GM体积相关（β = -0.077，P = 0.033）。在第二次复查时，未发现与MTA、WML或MRI测量有显著关联。
先前显示的中年工作相关压力与痴呆风险的关联可能至少部分由与晚年较低GM体积的关联来解释。第二次复查时缺乏关联可能表明中年工作相关压力影响的关键时间窗口，和/或选择性生存/参与。
