Department of Pediatric Surgery, Medical University of Vienna, A-1090 Vienna, Austria.
J Pediatr Surg. 2012 Aug;47(8):1548-54. doi: 10.1016/j.jpedsurg.2011.11.049.
The aim of this study was to test the predictive value of interleukin (IL) 8 in the assessment of intestinal involvement in necrotizing enterocolitis (NEC).
Forty infants with surgically treated NEC were classified into 3 groups based on intestinal involvement during laparotomy: focal (n = 11), multifocal (n = 16), and panintestinal (n = 13). Preoperatively obtained serum levels of IL-8, C-reactive protein, white blood cell count, and platelet count were correlated with intestinal involvement using logistic regression models.
Interleukin 8 correlated significantly with intestinal involvement in infants with surgically treated NEC (odds ratio, 1.74; confidence interval, 1.27-2.39; P < .001). An exploratory IL-8 cutoff value of 449 pg/mL provided a specificity of 81.8% and sensitivity of 82.8% to discriminate focal from multifocal and panintestinal disease. An IL-8 cutoff value of 1388 pg/mL provided a specificity of 77.8% and a sensitivity of 76.9% to discriminate panintestinal disease from focal and multifocal disease.
To our knowledge, this is the first study to demonstrate a significant correlation of IL-8 with intestinal involvement in advanced NEC in a large patient population. Our results indicate that IL-8 may be a promising biomarker for assessing intestinal involvement in infants with advanced NEC.
本研究旨在检验白细胞介素（IL）8 在预测坏死性小肠结肠炎（NEC）肠内受累中的价值。
根据剖腹术中肠受累情况，将 40 例接受手术治疗的 NEC 患儿分为 3 组：局灶性（n=11）、多灶性（n=16）和全肠性（n=13）。使用逻辑回归模型将术前获得的血清 IL-8、C 反应蛋白、白细胞计数和血小板计数与肠受累情况相关联。
IL-8 与接受手术治疗的 NEC 患儿的肠内受累情况显著相关（比值比，1.74；置信区间，1.27-2.39；P<.001）。IL-8 的截断值为 449 pg/mL 时，对区分局灶性和多灶性疾病具有 81.8%的特异性和 82.8%的敏感性；截断值为 1388 pg/mL 时，对区分全肠性疾病与局灶性和多灶性疾病具有 77.8%的特异性和 76.9%的敏感性。
据我们所知，这是第一项在大型患者人群中证明白细胞介素 8 与晚期 NEC 肠内受累显著相关的研究。我们的研究结果表明，IL-8 可能是评估重症 NEC 患儿肠内受累的有前途的生物标志物。
