儿童癫痫的[123I-异碘安非他明单光子发射计算机断层扫描（SPECT）研究]

[123I-IMP single photon emission computed tomography (SPECT) study in childhood epilepsy].

作者信息

Hara M, Shimomura O, Kojima A, Izunaga H, Tomiguchi S, Hirota Y, Taku K, Miike T, Takahashi M

机构信息

Department of Radiology, Kumamoto University School of Medicine.

出版信息

Kaku Igaku. 1990 Nov;27(11):1239-45.

PMID:2290192

Abstract

N-isopropyl-p[123I]-iodoamphetamine (IMP) single photon emission computed tomography (SPECT), X-ray computed tomography (X-CT) and magnetic resonance imaging (MRI) were performed in 18 children with idiopathic seizures. In children with idiopathic seizures SPECT identified abnormal lesions in the highest rate (50%) compared with X-CT (11%) and MRI (13%), but the findings of SPECT poorly correlated with the foci on electroencephalography (EEG). Idiopathic epilepsy with abnormal uptake on SPECT was refractory to medical treatments and frequently associated with mental and/or developmental retardation. Perfusion defects identified on SPECT probably influenced the development of the brains in children. IMP SPECT is useful in the diagnosis and medical treatment in children with seizures.

摘要

对18例特发性癫痫患儿进行了N-异丙基-p[123I]-碘安非他明（IMP）单光子发射计算机断层扫描（SPECT）、X线计算机断层扫描（X-CT）和磁共振成像（MRI）检查。在特发性癫痫患儿中，SPECT发现异常病灶的比例最高（50%），高于X-CT（11%）和MRI（13%），但SPECT的检查结果与脑电图（EEG）的病灶相关性较差。SPECT显示摄取异常的特发性癫痫对药物治疗无效，且常伴有智力和/或发育迟缓。SPECT发现的灌注缺损可能影响了儿童大脑的发育。IMP SPECT对癫痫患儿的诊断和治疗有帮助。