Takishima T, Machida K, Honda N, Mamiya T, Takahashi T, Kamano T, Hasegawa N
Department of Radiology, Saitama Medical Center, Saitama Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Mar 25;50(3):278-85.
Single photon emission computed tomography (SPECT) of the brain using N-isopropyl p-I-123-iodoamphetamine (I-123 IMP) was performed in 43 children with suspected brain diseases. Forty-three children (25 males and 18 females), with an age range of 24 days-15 years (mean: 6.6 years), were included in the study. Six patients were subsequently diagnosed as normal. Early SPECT of the brain was performed 30 minutes after intravenous administration of 74-111 MBq (2-3 mCi) I-123 IMP using a rotating gamma camera equipped with a 30-degree slant hole and medium energy collimator. Transverse images were reconstructed by Shepp-Logan filtered back projection method with attenuation correction after spatial filtering using an 8th order Butterworth-Wiener filter. Findings of I-123 IMP SPECT were compared with those of X-ray computed tomography (CT) and electroencephalography (EEG). The results showed that 1) In I-123 IMP SPECT, abnormality was found in 30 out of 37 children with brain diseases. The incidence of abnormal findings in the 37 patients was 81% in I-123 IMP SPECT, 61% in X-ray CT, and 78% in EEG., 2) In both cryptogenic and secondary epilepsy, the incidence of abnormality was higher in I-123 IMP SPECT than in X-ray CT. (70% and 94% vs 50% and 81% respectively). Epileptic foci detected by EEG did not correspond with defects found using I-123 IMP SPECT in 27% of the patients., 3) In asphyxiated infants, a high incidence of abnormality was observed on both I-123 IMP SPECT (86%) and X-ray CT (86%).(ABSTRACT TRUNCATED AT 250 WORDS)
对43例疑似脑部疾病的儿童进行了使用N-异丙基-p-I-123-碘安非他明（I-123 IMP）的脑部单光子发射计算机断层扫描（SPECT）。研究纳入了43名儿童（25名男性和18名女性），年龄范围为24天至15岁（平均：6.6岁）。6名患者随后被诊断为正常。在静脉注射74 - 111 MBq（2 - 3 mCi）I-123 IMP后30分钟，使用配备30度斜孔和中能准直器的旋转γ相机进行早期脑部SPECT。使用8阶巴特沃斯 - 维纳滤波器进行空间滤波后，通过带有衰减校正的Shepp-Logan滤波反投影法重建横向图像。将I-123 IMP SPECT的结果与X射线计算机断层扫描（CT）和脑电图（EEG）的结果进行比较。结果显示：1）在I-123 IMP SPECT中，37例脑部疾病儿童中有30例发现异常。37例患者中异常发现的发生率在I-123 IMP SPECT中为81%，在X射线CT中为61%，在EEG中为78%。2）在隐源性癫痫和继发性癫痫中，I-123 IMP SPECT中异常的发生率均高于X射线CT。（分别为70%和94%对50%和81%）。在27%的患者中，EEG检测到的癫痫灶与使用I-123 IMP SPECT发现的缺损不对应。3）在窒息婴儿中，I-123 IMP SPECT（86%）和X射线CT（86%）上均观察到高异常发生率。（摘要截断于250字）
