Matsunari I, Bunko H, Nakajima K, Taki J, Shiire Y, Hisada K
Department of Nuclear Medicine, School of Medicine, Kanazawa University.
Kaku Igaku. 1990 Nov;27(11):1265-72.
Factor analysis, a new method of functional imaging, has been applied to cardiovascular nuclear medicine. Because of the difficulty of its interpretation, it has not been popular as a method for detecting abnormal wall motion. The purpose of this study was to evaluate the usefulness of factor analysis in exercise gated blood-pool study in patients with ischemic heart disease. In our factor analysis, left ventricular region of interest (LVROI) was extracted to exclude the surrounding radioactivities. The new method was compared with 1) the conventional factor analysis using whole region (whole ROI method), and with 2) the other functional images, i.e. stroke volume, ejection fraction and phase images. At first we tried 3-factor analysis of the LVROI method, which resulted in many uninterpretable factors. Whereas in 2-factor analysis no uninterpretable factors were extracted. In comparison with cine-mode display, the LVROI method with 2-factor analysis showed the best sensitivity (85%) and specificity (100%). In exercise gated blood-pool study, it became easier to detect abnormal wall motion by comparing the factor image at exercise with resting image. In conclusion, the 2-factor analysis using the LVROI method greatly improved the limitation of conventional factor analysis, and will be useful in detecting wall motion abnormality in patients with ischemic heart disease.
因子分析作为一种功能成像的新方法，已应用于心血管核医学领域。由于其解释难度较大，作为一种检测室壁运动异常的方法尚未得到广泛应用。本研究的目的是评估因子分析在缺血性心脏病患者运动门控心血池研究中的应用价值。在我们的因子分析中，提取左心室感兴趣区（LVROI）以排除周围放射性。将这种新方法与1）使用整个区域的传统因子分析（全ROI法）以及2）其他功能图像，即每搏输出量、射血分数和相位图像进行比较。首先，我们尝试了LVROI法的三因子分析，结果产生了许多无法解释的因子。而在二因子分析中未提取到无法解释的因子。与电影模式显示相比，采用二因子分析的LVROI法显示出最佳的敏感性（85%）和特异性（100%）。在运动门控心血池研究中，通过比较运动时与静息时的因子图像，更容易检测到室壁运动异常。总之，使用LVROI法的二因子分析极大地改善了传统因子分析的局限性，将有助于检测缺血性心脏病患者的室壁运动异常。
