Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 52074 Aachen, Germany.
Trends Cardiovasc Med. 2012 Nov;22(8):197-201. doi: 10.1016/j.tcm.2012.07.020. Epub 2012 Aug 16.
Fetuin-A is a liver-derived plasma protein involved in calcified matrix metabolism. Fetuin-A mediates the formation and stabilization of calciprotein particles (CPPs), soluble colloids made of fetuin-A, further serum proteins, and calcium phosphate mineral. CPP formation ensures mineral solubilization and rapid clearance from circulation by macrophages of the mononuclear phagocyte system, thus preventing pathological calcification. Accordingly, low levels of free serum fetuin-A and high serum CPPs are associated with pathological calcification in patients suffering from chronic kidney disease.
胎球蛋白 A 是一种肝脏来源的血浆蛋白，参与钙化基质代谢。胎球蛋白 A 介导钙磷蛋白颗粒（CPPs）的形成和稳定，CPPs 是由胎球蛋白 A、进一步的血清蛋白和磷酸钙矿物质组成的可溶性胶体。CPP 的形成确保了矿物质的溶解，并通过单核吞噬细胞系统的巨噬细胞迅速从循环中清除，从而防止病理性钙化。因此，慢性肾病患者血清中游离胎球蛋白 A 水平低和血清 CPPs 水平高与病理性钙化有关。
